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Pharmaceutics 2018, 10(4), 284; https://doi.org/10.3390/pharmaceutics10040284

HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy

1
Institute of Fine Chemical Technology, Moscow Technological University (MIREA), 86 Vernadsky Avenue, Moscow 119571, Russia
2
Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, Russia
3
Laboratory of Biomedical Nanomaterials, National Research Technological University “MISiS”, Leninskiy Prospekt 4, Moscow 119049, Russia
4
FSBI NMRRC of the Ministry of Health of the Russian Federation, 2-Y Botkinskiy Proyezd 3, Moscow 125284, Russia
5
Skolkovo Institute of Science and Technology, Nobelya Ulitsa 3, Moscow 121205, Russia
6
Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq., 9, Moscow 125047, Russia
7
Department of Chemistry, Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia
*
Author to whom correspondence should be addressed.
Received: 5 November 2018 / Revised: 13 December 2018 / Accepted: 13 December 2018 / Published: 17 December 2018
(This article belongs to the Special Issue Nanotheranostics and Cancer: Where Are We Now?)
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PDF [2131 KB, uploaded 17 December 2018]
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Abstract

Background: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity for tracking drug accumulation in dynamics using non-invasive magnetic resonance imaging (MRI). The purpose of the study was to evaluate MNP loaded with PS as a theranostic tool for treating cancer in mice xenograft colon cancer models. Methods: MNPs coated with human serum albumin (HSA) were loaded with bacteriochlorine a. MRI, atomic emission spectroscopy (AES) and fluorescent imaging were used to study MNP and drug accumulation rates and dynamics in CT26 tumors. Tumor growth curves were evaluated in animals that received PDT at different time points upon MNP systemic injection. Results: Peak MNP accumulation in tumors was detected by MRI 60 min post injection (pi) and the data were verified by AES and fluorescent imaging. Up to 17% of injected dose/g of tissue was delivered to malignant tissues 24 h after injection. Consistent with MRI predicted drug accumulation peak PDT performed 60 min after intravenous injection was more efficient in inhibiting tumor growth than treatment scheduled 30 min and 240 min pi. Conclusions: PS loading on HAS-coated MNPs is a perspective approach to increase drug delivery to tumor site. Tracking for MNP accumulation by MRI can be used to predict drug concentration peak in tumors and to adjust PDT time scheduling for improved antitumor response. View Full-Text
Keywords: Photodynamic therapy; iron oxide nanoparticles; human serum albumin; MRI Photodynamic therapy; iron oxide nanoparticles; human serum albumin; MRI
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ostroverkhov, P.; Semkina, A.; Naumenko, V.; Plotnikova, E.; Yakubovskaya, R.; Vodopyanov, S.; Abakumov, A.; Majouga, A.; Grin, M.; Chekhonin, V.; Abakumov, M. HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy. Pharmaceutics 2018, 10, 284.

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