Next Article in Journal
Aminoguanidine Protects Boar Spermatozoa against the Deleterious Effects of Oxidative Stress
Previous Article in Journal
Prospects and Challenges of Phospholipid-Based Prodrugs
Open AccessArticle

Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin

1
Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
2
uPRAX Microsolutions B.V., Molengraaffsingel 12, 2623 JD Delft, The Netherlands
3
Tyndall National Institute, University College Cork, T12 R5CP Cork, Ireland
4
Institute for Translational Vaccinology, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands
*
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(4), 211; https://doi.org/10.3390/pharmaceutics10040211
Received: 10 October 2018 / Revised: 26 October 2018 / Accepted: 28 October 2018 / Published: 1 November 2018
Microneedle technologies have been developed for dermal drug and vaccine delivery, including hollow-, solid-, coated-, and dissolving microneedles. Microneedles have been made in many different geometries and of many different materials, all of which may influence their skin-penetrating ability. To ensure reproducible and effective drug and vaccine delivery via microneedles, the optimal insertion parameters should be known. Therefore, a digitally-controlled microneedle applicator was developed to insert microneedles into the skin via impact insertion (velocity) or via pressing force insertion. Six microneedle arrays with different geometries and/or materials were applied onto ex vivo human skin with varying velocities or pressing forces. Penetration efficiency and delivered antigen dose into the skin after application of microneedles were determined. In general, microneedles pierced the skin more efficiently when applied by impact application as compared to application via pressing force. However, the angle of application of the applicator on the skin can affect the velocity of the impact, influencing the penetration efficiency of microneedles. Regarding the antigen delivery into the skin, the delivered dose was increasing by increasing the velocity or pressure, and thus, increasing the penetration efficiency. These data demonstrate that an applicator is an important tool to determine optimal application conditions with ex vivo human skin. View Full-Text
Keywords: microneedle arrays; impact applicator; pressing force applicator; skin penetration; (trans)dermal drug/vaccine delivery microneedle arrays; impact applicator; pressing force applicator; skin penetration; (trans)dermal drug/vaccine delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Leone, M.; Van Oorschot, B.H.; Nejadnik, M.R.; Bocchino, A.; Rosato, M.; Kersten, G.; O’Mahony, C.; Bouwstra, J.; Van der Maaden, K. Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin. Pharmaceutics 2018, 10, 211. https://doi.org/10.3390/pharmaceutics10040211

AMA Style

Leone M, Van Oorschot BH, Nejadnik MR, Bocchino A, Rosato M, Kersten G, O’Mahony C, Bouwstra J, Van der Maaden K. Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin. Pharmaceutics. 2018; 10(4):211. https://doi.org/10.3390/pharmaceutics10040211

Chicago/Turabian Style

Leone, Mara; Van Oorschot, Bart H.; Nejadnik, M. R.; Bocchino, Andrea; Rosato, Matteo; Kersten, Gideon; O’Mahony, Conor; Bouwstra, Joke; Van der Maaden, Koen. 2018. "Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin" Pharmaceutics 10, no. 4: 211. https://doi.org/10.3390/pharmaceutics10040211

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop