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Pharmaceutics 2018, 10(3), 97; https://doi.org/10.3390/pharmaceutics10030097

A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

1
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Via Orabona 4, 70125 Bari, Italy
2
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
3
Consiglio Nazionale delle Ricerche-Istituto di Fotonica e Nanotecnologie (CNR-IFN) Bari, Via Amendola 173, 70125 Bari, Italy
*
Author to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 15 July 2018 / Accepted: 16 July 2018 / Published: 19 July 2018
(This article belongs to the Special Issue Micro and Nano Encapsulation Techniques)
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Abstract

Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present. View Full-Text
Keywords: inulin; vitamin E; micelle; hydrogel; dual delivery; curcumin; beclometasone; drug delivery; colon delivery; combination therapy inulin; vitamin E; micelle; hydrogel; dual delivery; curcumin; beclometasone; drug delivery; colon delivery; combination therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mandracchia, D.; Trapani, A.; Perteghella, S.; Di Franco, C.; Torre, M.L.; Calleri, E.; Tripodo, G. A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs. Pharmaceutics 2018, 10, 97.

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