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Chitosan Loaded into a Hydrogel Delivery System as a Strategy to Treat Vaginal Co-Infection

School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino (MC), Italy
Department of Biomolecular Sciences, University of Urbino, Piazza del Rinascimento n° 6, 61029 Urbino (PU), Italy
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo n° 5, 35131 Padova (PD), Italy
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(1), 23;
Received: 22 December 2017 / Revised: 27 January 2018 / Accepted: 1 February 2018 / Published: 3 February 2018
(This article belongs to the Special Issue Chitosan Biomedical Applications: Opportunities and Challenges)
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Polymeric hydrogels are common dosage forms designed for the topical administration of antimicrobial drugs to treat vaginal infections. One of the major advantages of using chitosan in these formulations is related to the intrinsic and broad antimicrobial activity exerted on bacteria and fungi by this natural polymer. Most vaginal yeast infections are caused by the pathogenic fungus Candida albicans. However, despite the anti-Candida activity towards and strains susceptibility to low molecular weight chitosan being documented, no information is available regarding the antimicrobial efficacy of mixed hydrogels in which chitosan is dispersed in a polymeric matrix. Therefore, the aim of the study is to evaluate the anti-Candida activity against eight different albicans and non-albicans strains of a mixed hydroxypropyl methylcellulose (HPMC)/chitosan hydrogel. Importantly, chitosan was dispersed in HPMC matrix either assembled in nanoparticles or in a monomolecular state to eventually correlate any variation in terms of rheological and mucoadhesive properties, as well as anti-Candida activity, with the chitosan form. Hydrogels containing 1% w/w chitosan, either as free polymer chain or assembled in nanoparticles, showed an improved mucoadhesiveness and an anti-Candida effect against all tested albicans and non-albicans strains. Overall, the results demonstrate the feasibility of preparing HPMC/CS mixed hydrogels intended for the prevention and treatment of Candida infections after vaginal administration. View Full-Text
Keywords: mixed hydrogels; nanoparticles; Minimum Inhibitory Concentration (MIC); mucoadhesiveness; Candida spp. mixed hydrogels; nanoparticles; Minimum Inhibitory Concentration (MIC); mucoadhesiveness; Candida spp.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Perinelli, D.R.; Campana, R.; Skouras, A.; Bonacucina, G.; Cespi, M.; Mastrotto, F.; Baffone, W.; Casettari, L. Chitosan Loaded into a Hydrogel Delivery System as a Strategy to Treat Vaginal Co-Infection. Pharmaceutics 2018, 10, 23.

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