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Viruses 2017, 9(11), 329;

Structure and Function of Caliciviral RNA Polymerases

Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Korea
Department of Food and Nutrition, Duksung Women’s University, Seoul 01369, Korea
Author to whom correspondence should be addressed.
Received: 15 September 2017 / Revised: 26 October 2017 / Accepted: 2 November 2017 / Published: 6 November 2017
(This article belongs to the Special Issue Structure-Function Relationships in Viral Polymerases)
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Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available. Since the rapid rate of genetic evolution of caliciviruses is mainly due to the error-prone nature of RNA-dependent RNA polymerase (RdRp), this article focuses on recent studies of the structures and functions of RdRp from caliciviruses. It also provides recent advances in the interactions of RdRp with virion protein genome-linked (VPg) and RNA and the structural and functional features of its precursor. View Full-Text
Keywords: calicivirus; polymerase; structure; interaction; precursor calicivirus; polymerase; structure; interaction; precursor

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lee, J.-H.; Chung, M.S.; Kim, K.H. Structure and Function of Caliciviral RNA Polymerases. Viruses 2017, 9, 329.

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