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Viruses 2016, 8(8), 230;

Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80521, USA
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia
Author to whom correspondence should be addressed.
Academic Editor: Andrew Mehle
Received: 17 June 2016 / Revised: 26 July 2016 / Accepted: 13 August 2016 / Published: 19 August 2016
(This article belongs to the Section Animal Viruses)
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The Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized in 2012 and can cause severe disease in infected humans. Dromedary camels are the reservoir for the virus, although, other than nasal discharge, these animals do not display any overt clinical disease. Data from in vitro experiments suggest that other livestock such as sheep, goats, and horses might also contribute to viral transmission, although field data has not identified any seropositive animals. In order to understand if these animals could be infected, we challenged young goats and horses and adult sheep with MERS-CoV by intranasal inoculation. Minimal or no virus shedding was detected in all of the animals. During the four weeks following inoculation, neutralizing antibodies were detected in the young goats, but not in sheep or horses. View Full-Text
Keywords: MERS; horse; goat; sheep; reservoir host MERS; horse; goat; sheep; reservoir host

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Adney, D.R.; Brown, V.R.; Porter, S.M.; Bielefeldt-Ohmann, H.; Hartwig, A.E.; Bowen, R.A. Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding. Viruses 2016, 8, 230.

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