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Viruses 2016, 8(8), 229;

Role of Envelopment in the HEV Life Cycle

Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA
Author to whom correspondence should be addressed.
Academic Editor: Jacques Izopet
Received: 30 June 2016 / Revised: 2 August 2016 / Accepted: 11 August 2016 / Published: 18 August 2016
(This article belongs to the Special Issue Recent Progress in Hepatitis E Virus Research)
Full-Text   |   PDF [895 KB, uploaded 18 August 2016]   |  


Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient’s blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery of this novel enveloped form of HEV has raised a series of questions about the fundamental biology of HEV and the way this virus, which has been understudied in the past, interacts with its host. Here, we review recent advances towards understanding this phenomenon and discuss its potential impact on various aspects of the HEV life cycle and immunity. View Full-Text
Keywords: hepatitis E virus; quasi-envelopment hepatitis E virus; quasi-envelopment

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yin, X.; Li, X.; Feng, Z. Role of Envelopment in the HEV Life Cycle. Viruses 2016, 8, 229.

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