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Use of Cellular Decapping Activators by Positive-Strand RNA Viruses

Molecular Virology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain
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Academic Editor: J. Robert Hogg
Viruses 2016, 8(12), 340; https://doi.org/10.3390/v8120340
Received: 24 October 2016 / Revised: 6 December 2016 / Accepted: 19 December 2016 / Published: 21 December 2016
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5′-3′ mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus. View Full-Text
Keywords: mRNA decay; positive strand RNA viruses; virus–host interactions mRNA decay; positive strand RNA viruses; virus–host interactions
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Jungfleisch, J.; Blasco-Moreno, B.; Díez, J. Use of Cellular Decapping Activators by Positive-Strand RNA Viruses. Viruses 2016, 8, 340.

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