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Viruses 2016, 8(10), 292;

In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection

Laboratoire de Virologie, Hôpitaux Universitaires de Strasbourg, 3 rue Koeberlé, 67000 Strasbourg, France
Université de Strasbourg, INSERM, IRM UMR-S 1109, 4 rue Kirschleger, 67000 Strasbourg, France
Author to whom correspondence should be addressed.
Academic Editor: Alexander Ploss
Received: 4 August 2016 / Revised: 22 September 2016 / Accepted: 13 October 2016 / Published: 22 October 2016
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Developments of genome amplification techniques have rapidly expanded the family of human polyomaviruses (PyV). Following infection early in life, PyV persist in their hosts and are generally of no clinical consequence. High-level replication of PyV can occur in patients under immunosuppressive or immunomodulatory therapy and causes severe clinical entities, such as progressive multifocal leukoencephalopathy, polyomavirus-associated nephropathy or Merkel cell carcinoma. The characterization of known and newly-discovered human PyV, their relationship to human health, and the mechanisms underlying pathogenesis remain to be elucidated. Here, we summarize the most widely-used in vitro and in vivo models to study the PyV-host interaction, pathogenesis and anti-viral drug screening. We discuss the strengths and limitations of the different models and the lessons learned. View Full-Text
Keywords: polyomavirus; in vitro models; animal models; tropism; entry; pathogenesis polyomavirus; in vitro models; animal models; tropism; entry; pathogenesis

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Barth, H.; Solis, M.; Kack-Kack, W.; Soulier, E.; Velay, A.; Fafi-Kremer, S. In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection. Viruses 2016, 8, 292.

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