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Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection

by Yaqin Zhou and Ying Zhu *
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
*
Author to whom correspondence should be addressed.
Academic Editor: Andrew Mehle
Viruses 2015, 7(6), 3116-3129; https://doi.org/10.3390/v7062762
Received: 27 April 2015 / Accepted: 11 June 2015 / Published: 16 June 2015
(This article belongs to the Special Issue Gene Technology and Resistance to Viruses - Reviews)
The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies have discovered the antiviral effects induced by IL-32 and its associated regulatory mechanisms. The interactions between IL-32 and various cytokines including cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interferon (IFN)-λ1, interleukin (IL)-6, and soluble IL-6 receptor have been described. This review aims to integrate these new findings into explicit concepts and raises the intriguing possibility of IL-32 as a therapeutic target. View Full-Text
Keywords: interleukin-32; pro-inflammatory cytokine; virus infection; antiviral activities interleukin-32; pro-inflammatory cytokine; virus infection; antiviral activities
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Zhou, Y.; Zhu, Y. Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection. Viruses 2015, 7, 3116-3129.

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