Genetic Characterization of the Tick-Borne Orbiviruses
AbstractThe International Committee for Taxonomy of Viruses (ICTV) recognizes four species of tick-borne orbiviruses (TBOs): Chenuda virus, Chobar Gorge virus, Wad Medani virus and Great Island virus (genus Orbivirus, family Reoviridae). Nucleotide (nt) and amino acid (aa) sequence comparisons provide a basis for orbivirus detection and classification, however full genome sequence data were only available for the Great Island virus species. We report representative genome-sequences for the three other TBO species (virus isolates: Chenuda virus (CNUV); Chobar Gorge virus (CGV) and Wad Medani virus (WMV)). Phylogenetic comparisons show that TBOs cluster separately from insect-borne orbiviruses (IBOs). CNUV, CGV, WMV and GIV share low level aa/nt identities with other orbiviruses, in ‘conserved’ Pol, T2 and T13 proteins/genes, identifying them as four distinct virus-species. The TBO genome segment encoding cell attachment, outer capsid protein 1 (OC1), is approximately half the size of the equivalent segment from insect-borne orbiviruses, helping to explain why tick-borne orbiviruses have a ~1 kb smaller genome. View Full-Text
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Belaganahalli, M.N.; Maan, S.; Maan, N.S.; Brownlie, J.; Tesh, R.; Attoui, H.; Mertens, P.P.C. Genetic Characterization of the Tick-Borne Orbiviruses. Viruses 2015, 7, 2185-2209.
Belaganahalli MN, Maan S, Maan NS, Brownlie J, Tesh R, Attoui H, Mertens PPC. Genetic Characterization of the Tick-Borne Orbiviruses. Viruses. 2015; 7(5):2185-2209.Chicago/Turabian Style
Belaganahalli, Manjunatha N.; Maan, Sushila; Maan, Narender S.; Brownlie, Joe; Tesh, Robert; Attoui, Houssam; Mertens, Peter P.C. 2015. "Genetic Characterization of the Tick-Borne Orbiviruses." Viruses 7, no. 5: 2185-2209.