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Article

Genetic Characterization of the Tick-Borne Orbiviruses

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Vector-borne Viral Diseases Programme, The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
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Department of Animal Biotechnology, LLR University of Veterinary and Animal Sciences, Hisar 125 004, Haryana, India
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Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
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Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555–0609, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Viruses 2015, 7(5), 2185-2209; https://doi.org/10.3390/v7052185
Received: 2 February 2015 / Revised: 18 March 2015 / Accepted: 21 April 2015 / Published: 28 April 2015
(This article belongs to the Section Animal Viruses)
The International Committee for Taxonomy of Viruses (ICTV) recognizes four species of tick-borne orbiviruses (TBOs): Chenuda virus, Chobar Gorge virus, Wad Medani virus and Great Island virus (genus Orbivirus, family Reoviridae). Nucleotide (nt) and amino acid (aa) sequence comparisons provide a basis for orbivirus detection and classification, however full genome sequence data were only available for the Great Island virus species. We report representative genome-sequences for the three other TBO species (virus isolates: Chenuda virus (CNUV); Chobar Gorge virus (CGV) and Wad Medani virus (WMV)). Phylogenetic comparisons show that TBOs cluster separately from insect-borne orbiviruses (IBOs). CNUV, CGV, WMV and GIV share low level aa/nt identities with other orbiviruses, in ‘conserved’ Pol, T2 and T13 proteins/genes, identifying them as four distinct virus-species. The TBO genome segment encoding cell attachment, outer capsid protein 1 (OC1), is approximately half the size of the equivalent segment from insect-borne orbiviruses, helping to explain why tick-borne orbiviruses have a ~1 kb smaller genome. View Full-Text
Keywords: Chenuda virus; Chobar Gorge virus; Wad Medani virus; Great Island virus; Kemorovo virus; Orbivirus; Reoviridae; full genome; dsRNA virus; sequencing Chenuda virus; Chobar Gorge virus; Wad Medani virus; Great Island virus; Kemorovo virus; Orbivirus; Reoviridae; full genome; dsRNA virus; sequencing
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MDPI and ACS Style

Belaganahalli, M.N.; Maan, S.; Maan, N.S.; Brownlie, J.; Tesh, R.; Attoui, H.; Mertens, P.P.C. Genetic Characterization of the Tick-Borne Orbiviruses. Viruses 2015, 7, 2185-2209. https://doi.org/10.3390/v7052185

AMA Style

Belaganahalli MN, Maan S, Maan NS, Brownlie J, Tesh R, Attoui H, Mertens PPC. Genetic Characterization of the Tick-Borne Orbiviruses. Viruses. 2015; 7(5):2185-2209. https://doi.org/10.3390/v7052185

Chicago/Turabian Style

Belaganahalli, Manjunatha N., Sushila Maan, Narender S. Maan, Joe Brownlie, Robert Tesh, Houssam Attoui, and Peter P.C. Mertens 2015. "Genetic Characterization of the Tick-Borne Orbiviruses" Viruses 7, no. 5: 2185-2209. https://doi.org/10.3390/v7052185

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