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Article

The Association between Hantavirus Infection and Selenium Deficiency in Mainland China

1
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
2
Department of Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3015CE, The Netherlands
3
Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China
4
Environmental and Global Health, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
5
Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
6
Ministry of Education Key Laboratory for Earth System Modeling, and Center for Earth System Science, Tsinghua University, Beijing 100084, China
7
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000CA, The Netherlands
8
National Center for Public Health Surveillance and Information Service, Chinese Center for Disease Control and Prevention, Beijing 102206, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Eric O. Freed
Viruses 2015, 7(1), 333-351; https://doi.org/10.3390/v7010333
Received: 27 October 2014 / Revised: 9 January 2015 / Accepted: 19 January 2015 / Published: 20 January 2015
Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach combining ecological analysis with preliminary experimental data. The incidence of HFRS in humans was about six times higher in severe selenium-deficient and double in moderate deficient areas compared to non-deficient areas. This association became statistically stronger after correction for other significant environment-related factors (low elevation, few grasslands, or an abundance of forests) and was independent of geographical scale by separate analyses for different climate regions. A case-control study of HFRS patients admitted to the hospital revealed increased activity and plasma levels of selenium binding proteins while selenium supplementation in vitro decreased viral replication in an endothelial cell model after infection with a low multiplicity of infection (MOI). Viral replication with a higher MOI was not affected by selenium supplementation. Our findings indicate that selenium deficiency may contribute to an increased prevalence of hantavirus infections in both humans and rodents. Future studies are needed to further examine the exact mechanism behind this observation before selenium supplementation in deficient areas could be implemented for HFRS prevention. View Full-Text
Keywords: hemorrhagic fever with renal syndrome; selenium; hantavirus; rodents; environmental factors; China hemorrhagic fever with renal syndrome; selenium; hantavirus; rodents; environmental factors; China
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MDPI and ACS Style

Fang, L.-Q.; Goeijenbier, M.; Zuo, S.-Q.; Wang, L.-P.; Liang, S.; Klein, S.L.; Li, X.-L.; Liu, K.; Liang, L.; Gong, P.; Glass, G.E.; Van Gorp, E.; Richardus, J.H.; Ma, J.-Q.; Cao, W.-C.; De Vlas, S.J. The Association between Hantavirus Infection and Selenium Deficiency in Mainland China. Viruses 2015, 7, 333-351. https://doi.org/10.3390/v7010333

AMA Style

Fang L-Q, Goeijenbier M, Zuo S-Q, Wang L-P, Liang S, Klein SL, Li X-L, Liu K, Liang L, Gong P, Glass GE, Van Gorp E, Richardus JH, Ma J-Q, Cao W-C, De Vlas SJ. The Association between Hantavirus Infection and Selenium Deficiency in Mainland China. Viruses. 2015; 7(1):333-351. https://doi.org/10.3390/v7010333

Chicago/Turabian Style

Fang, Li-Qun; Goeijenbier, Marco; Zuo, Shu-Qing; Wang, Li-Ping; Liang, Song; Klein, Sabra L.; Li, Xin-Lou; Liu, Kun; Liang, Lu; Gong, Peng; Glass, Gregory E.; Van Gorp, Eric; Richardus, Jan H.; Ma, Jia-Qi; Cao, Wu-Chun; De Vlas, Sake J. 2015. "The Association between Hantavirus Infection and Selenium Deficiency in Mainland China" Viruses 7, no. 1: 333-351. https://doi.org/10.3390/v7010333

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