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Viruses 2014, 6(9), 3643-3651;

Stepping toward a Macaque Model of HIV-1 Induced AIDS

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM385, Houston, TX 77030, USA
Received: 6 August 2014 / Revised: 16 September 2014 / Accepted: 18 September 2014 / Published: 25 September 2014
(This article belongs to the Section Editorial)
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HIV-1 exhibits a narrow host range, hindering the development of a robust animal model of pathogenesis. Past studies have demonstrated that the restricted host range of HIV-1 may be largely due to the inability of the virus to antagonize and evade effector molecules of the interferon response in other species. They have also guided the engineering of HIV-1 clones that can replicate in CD4 T-cells of Asian macaque species. However, while replication of these viruses in macaque hosts is persistent, it has been limited and without progression to AIDS. In a new study, Hatziioannou et al., demonstrate for the first time that adapted macaque-tropic HIV-1 can persistently replicate at high levels in pigtailed macaques (Macaca nemestrina), but only if CD8 T-cells are depleted at the time of inoculation. The infection causes rapid disease and recapitulates several aspects of AIDS in humans. Additionally, the virus undergoes genetic changes to further escape innate immunity in association with disease progression. Here, the importance of these findings is discussed, as they relate to pathogenesis and model development. View Full-Text
Keywords: HIV-1; Macaca nemestrina; pathogenesis; AIDS; innate restriction HIV-1; Macaca nemestrina; pathogenesis; AIDS; innate restriction

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Kimata, J.T. Stepping toward a Macaque Model of HIV-1 Induced AIDS. Viruses 2014, 6, 3643-3651.

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