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Antigenic Properties of N Protein of Hantavirus

Department of Microbiology, Graduate School of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo 060-8638, Japan
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Viruses 2014, 6(8), 3097-3109; https://doi.org/10.3390/v6083097
Received: 6 June 2014 / Revised: 21 July 2014 / Accepted: 21 July 2014 / Published: 13 August 2014
(This article belongs to the Special Issue Hantaviruses)
Hantavirus causes two important rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in North and South America. Twenty-four species that represent sero- and genotypes have been registered within the genus Hantavirus by the International Committee on Taxonomy of Viruses (ICTV). Among the viral proteins, nucleocapsid (N) protein possesses an immunodominant antigen. The antigenicitiy of N protein is conserved compared with that of envelope glycoproteins. Therefore, N protein has been used for serological diagnoses and seroepidemiological studies. An understanding of the antigenic properties of N protein is important for the interpretation of results from serological tests using N antigen. N protein consists of about 430 amino acids and possesses various epitopes. The N-terminal quarter of N protein bears linear and immunodominant epitopes. However, a serotype-specific and multimerization-dependent antigenic site was found in the C-terminal half of N protein. In this paper, the structure, function, and antigenicity of N protein are reviewed. View Full-Text
Keywords: nucleocapsid; monoclonal antibody; epitope nucleocapsid; monoclonal antibody; epitope
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Yoshimatsu, K.; Arikawa, J. Antigenic Properties of N Protein of Hantavirus. Viruses 2014, 6, 3097-3109.

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