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RNA Virus Reverse Genetics and Vaccine Design

1
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
2
Children's Healthcare of Atlanta, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Viruses 2014, 6(7), 2531-2550; https://doi.org/10.3390/v6072531
Received: 30 April 2014 / Revised: 18 June 2014 / Accepted: 19 June 2014 / Published: 25 June 2014
(This article belongs to the Special Issue Virus-based Vaccines)
RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines. View Full-Text
Keywords: RNA virus; reverse genetics; vaccines RNA virus; reverse genetics; vaccines
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Stobart, C.C.; Moore, M.L. RNA Virus Reverse Genetics and Vaccine Design. Viruses 2014, 6, 2531-2550.

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