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Viruses 2013, 5(6), 1571-1586;

Bromodomain Proteins in HIV Infection

Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
Department of Medicine, University of California, San Francisco, CA 94158, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 13 May 2013 / Revised: 9 June 2013 / Accepted: 13 June 2013 / Published: 21 June 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
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Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency. View Full-Text
Keywords: bromodomains; HIV; PCAF; PBAF; p300; CBP; TRIM28; BRD2; BRD4 bromodomains; HIV; PCAF; PBAF; p300; CBP; TRIM28; BRD2; BRD4

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Boehm, D.; Conrad, R.J.; Ott, M. Bromodomain Proteins in HIV Infection. Viruses 2013, 5, 1571-1586.

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