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Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins

Division of Infectious Diseases, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, 181 Longwood Avenue, MCP 861, Boston, MA 02115, USA
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Viruses 2013, 5(5), 1231-1249; https://doi.org/10.3390/v5051231
Received: 10 April 2013 / Revised: 23 April 2013 / Accepted: 27 April 2013 / Published: 14 May 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic tumor suppressor pathway that thwarts expansion of cells that have suffered oncogenic hits. Infections with human cancer viruses including human papillomaviruses (HPVs) and Epstein-Barr virus can trigger oncogene-induced senescence, and the viruses have evolved strategies to abrogate this response in order to establish an infection and reprogram their host cells to establish a long-term persistent infection. As a consequence of inhibiting polycomb repression and evading oncogene induced-senescence, HPV infected cells have an altered epigenetic program as evidenced by aberrant homeobox gene expression. Similar alterations are frequently observed in non-virus associated human cancers and may be harnessed for diagnosis and therapy. View Full-Text
Keywords: cervical cancer; biomarker; histone methylation; tumor suppressor cervical cancer; biomarker; histone methylation; tumor suppressor
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McLaughlin-Drubin, M.E.; Munger, K. Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins. Viruses 2013, 5, 1231-1249.

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