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Open AccessOpinion

Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure?

Immunobiology of HIV Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, via Stamira D'Ancona 20, 20127 Milan, Italy
Viruses 2013, 5(2), 753-757; https://doi.org/10.3390/v5020753
Received: 11 January 2013 / Revised: 12 February 2013 / Accepted: 15 February 2013 / Published: 21 February 2013
(This article belongs to the Special Issue AIDS Vaccine 2014)
The SupT1 cell line supports optimal HIV-1 replication, and prolonged in vitro replication in SupT1 cells renders the virus significantly less virulent. This raises the question of whether the infusion of SupT1 cells could be used as a cell-based therapy to induce a pacific coexistence between the HIV virus and its human host. In a recent study, I investigated this potential therapeutic strategy in vitro. The results suggested that this approach should be further explored in HIV-susceptible animal models. Such studies may lead to the development of a functional cure for HIV infection. View Full-Text
Keywords: HIV infection; Functional cure; Cell-based therapy; Vif; APOBEC3G; SupT1 cells; HIV reservoir; CD4+ T cells HIV infection; Functional cure; Cell-based therapy; Vif; APOBEC3G; SupT1 cells; HIV reservoir; CD4+ T cells
MDPI and ACS Style

Fior, J. Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? Viruses 2013, 5, 753-757.

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