Next Article in Journal
Hiding Lipid Presentation: Viral Interference with CD1d-Restricted Invariant Natural Killer T (iNKT) Cell Activation
Next Article in Special Issue
Diversity and Adaptation of Human Respiratory Syncytial Virus Genotypes Circulating in Two Distinct Communities: Public Hospital and Day Care Center
Previous Article in Journal
Phosphoinositides in the Hepatitis C Virus Life Cycle
Article Menu

Export Article

Open AccessArticle
Viruses 2012, 4(10), 2359-2378;

Perinatal Lamb Model of Respiratory Syncytial Virus (RSV) Infection

Department of Veterinary Pathology, 2738 College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
Author to whom correspondence should be addressed.
Received: 25 September 2012 / Revised: 17 October 2012 / Accepted: 18 October 2012 / Published: 23 October 2012
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
Full-Text   |   PDF [1460 KB, uploaded 12 May 2015]   |  


Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in infants and children worldwide. Many animal models are used to study RSV, but most studies investigate disease in adult animals which does not address the unique physiology and immunology that makes infants more susceptible. The perinatal (preterm and term) lamb is a useful model of infant RSV disease as lambs have similar pulmonary structure including airway branching, Clara and type II cells, submucosal glands and Duox/lactoperoxidase (LPO) oxidative system, and prenatal alveologenesis. Lambs can be born preterm (90% gestation) and survive for experimentation although both preterm and term lambs are susceptible to ovine, bovine and human strains of RSV and develop clinical symptoms including fever, tachypnea, and malaise as well as mild to moderate gross and histologic lesions including bronchiolitis with epithelial injury, neutrophil infiltration and syncytial cell formation. RSV disease in preterm lambs is more severe than in term lambs; disease is progressively less in adults and age-dependent susceptibility is a feature similar to humans. Innate and adaptive immune responses by perinatal lambs closely parallel those of infants. The model is used to test therapeutic regimens, risk factors such as maternal ethanol consumption, and formalin inactivated RSV vaccines. View Full-Text
Keywords: airways; bronchiolitis; infants; innate immunity; lambs; lung; ovine; perinatal; premature; preterm; respiratory syncytial virus (RSV) airways; bronchiolitis; infants; innate immunity; lambs; lung; ovine; perinatal; premature; preterm; respiratory syncytial virus (RSV)

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Derscheid, R.J.; Ackermann, M.R. Perinatal Lamb Model of Respiratory Syncytial Virus (RSV) Infection. Viruses 2012, 4, 2359-2378.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top