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Viruses 2011, 3(6), 906-919;

RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications

Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Author to whom correspondence should be addressed.
Received: 9 April 2011 / Revised: 4 June 2011 / Accepted: 9 June 2011 / Published: 23 June 2011
(This article belongs to the Special Issue Antiviral Innate Immunity)
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The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection.
Keywords: RIG-I; inflammation; adjuvant RIG-I; inflammation; adjuvant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ireton, R.C.; Gale Jr., M. RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications. Viruses 2011, 3, 906-919.

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