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New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells

1
Institute for Molecular Virology, University of Minnesota, Minneapolis, 18-242 Moos Tower, 515 Delaware St. SE, Minneapolis, MN 55455, USA
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Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
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Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 5455, USA
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School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA
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Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Viruses 2011, 3(6), 770-793; https://doi.org/10.3390/v3060770
Received: 15 April 2011 / Revised: 20 May 2011 / Accepted: 20 May 2011 / Published: 14 June 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
Human T-cell leukemia virus type 1 (HTLV-1) has a reputation for being extremely difficult to study in cell culture. The challenges in propagating HTLV-1 has prevented a rigorous analysis of how these viruses replicate in cells, including the detailed steps involved in virus assembly. The details for how retrovirus particle assembly occurs are poorly understood, even for other more tractable retroviral systems. Recent studies on HTLV-1 using state-of-the-art cryo-electron microscopy and fluorescence-based biophysical approaches explored questions related to HTLV-1 particle size, Gag stoichiometry in virions, and Gag-Gag interactions in living cells. These results provided new and exciting insights into fundamental aspects of HTLV-1 particle assembly—which are distinct from those of other retroviruses, including HIV-1. The application of these and other novel biophysical approaches promise to provide exciting new insights into HTLV-1 replication.
Keywords: deltaretrovirus; lentivirus; spectroscopy; fluorescence; tomography deltaretrovirus; lentivirus; spectroscopy; fluorescence; tomography
MDPI and ACS Style

Fogarty, K.H.; Zhang, W.; Grigsby, I.F.; Johnson, J.L.; Chen, Y.; Mueller, J.D.; Mansky, L.M. New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells. Viruses 2011, 3, 770-793.

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