Next Article in Journal
Actin in Herpesvirus Infection
Previous Article in Journal
Efficient Sensing of Avian Influenza Viruses by Porcine Plasmacytoid Dendritic Cells
Article Menu

Article Versions

Export Article

Open AccessCommentary
Viruses 2011, 3(4), 331-335;

Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required?

Department of Microbiology and Immunology, McGill University, Duff Medical Building (D-6), 3775 University St., Montreal, QC, H3A 2B4, Canada
Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada
Received: 9 March 2011 / Revised: 1 April 2011 / Accepted: 1 April 2011 / Published: 12 April 2011
(This article belongs to the Section Editorial)
PDF [127 KB, uploaded 12 May 2015]


Liu and colleagues have recently studied dynamic changes in the orientation of HIV reverse transcriptase (RT) on its nucleic acid substrate during initiation of DNA synthesis. The authors employed a single molecule FRET assay and revealed the existence of an equilibrium between polymerase-competent and “flipped” polymerase-incompetent orientations. RT flipping correlates with enzyme pausing during initiation, while the transition to the processive elongation phase correlates with increases in the population of polymerase-competent complexes. The potential biological significance of these findings is discussed in this commentary in lieu of the entire process of reverse transcription.
Keywords: HIV; reverse transcription; initiation HIV; reverse transcription; initiation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Götte, M. Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required? Viruses 2011, 3, 331-335.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top