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Open AccessCommentary

Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required?

1
Department of Microbiology and Immunology, McGill University, Duff Medical Building (D-6), 3775 University St., Montreal, QC, H3A 2B4, Canada
2
Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada
Viruses 2011, 3(4), 331-335; https://doi.org/10.3390/v3040331
Received: 9 March 2011 / Revised: 1 April 2011 / Accepted: 1 April 2011 / Published: 12 April 2011
(This article belongs to the Section Editorial)
Liu and colleagues have recently studied dynamic changes in the orientation of HIV reverse transcriptase (RT) on its nucleic acid substrate during initiation of DNA synthesis. The authors employed a single molecule FRET assay and revealed the existence of an equilibrium between polymerase-competent and “flipped” polymerase-incompetent orientations. RT flipping correlates with enzyme pausing during initiation, while the transition to the processive elongation phase correlates with increases in the population of polymerase-competent complexes. The potential biological significance of these findings is discussed in this commentary in lieu of the entire process of reverse transcription.
Keywords: HIV; reverse transcription; initiation HIV; reverse transcription; initiation
MDPI and ACS Style

Götte, M. Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required? Viruses 2011, 3, 331-335.

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