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Dendritic Cells and HIV-1 Trans-Infection

Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Viruses 2010, 2(8), 1704-1717; https://doi.org/10.3390/v2081704
Received: 22 July 2010 / Accepted: 9 August 2010 / Published: 17 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease. View Full-Text
Keywords: myeloid dendritic cell; C-type lectin receptor; antigen presentation; trans-infection; infectious synapse myeloid dendritic cell; C-type lectin receptor; antigen presentation; trans-infection; infectious synapse
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MDPI and ACS Style

McDonald, D. Dendritic Cells and HIV-1 Trans-Infection. Viruses 2010, 2, 1704-1717. https://doi.org/10.3390/v2081704

AMA Style

McDonald D. Dendritic Cells and HIV-1 Trans-Infection. Viruses. 2010; 2(8):1704-1717. https://doi.org/10.3390/v2081704

Chicago/Turabian Style

McDonald, David. 2010. "Dendritic Cells and HIV-1 Trans-Infection" Viruses 2, no. 8: 1704-1717. https://doi.org/10.3390/v2081704

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