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Open AccessEditorial

Towards Viral Genome Annotation Standards, Report from the 2010 NCBI Annotation Workshop

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35222, USA
Swiss Institute of Bioinformatics, 1211 Genève 4, Switzerland
Laboratoire de Bioinformatique des Génomes et des Réseaux, Université Libre de Bruxelles, B-1050 Bruxelles, Belgium
J. Craig Venter Institute, Rockville, MD 20850, USA
Department of Pathology and Division of Biomedical Informatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Department of Bioinformatics and Computational Biology, George Mason University, Manassas, VA 20110, USA
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
Broad Institute, Cambridge, MA 02141, USA
Author to whom correspondence should be addressed.
Viruses 2010, 2(10), 2258-2268;
Received: 26 August 2010 / Revised: 18 September 2010 / Accepted: 20 September 2010 / Published: 13 October 2010
(This article belongs to the Special Issue Viral Genomics and Bioinformatics)
PDF [84 KB, uploaded 12 May 2015]


Improvements in DNA sequencing technologies portend a new era in virology and could possibly lead to a giant leap in our understanding of viral evolution and ecology. Yet, as viral genome sequences begin to fill the world’s biological databases, it is critically important to recognize that the scientific promise of this era is dependent on consistent and comprehensive genome annotation. With this in mind, the NCBI Genome Annotation Workshop recently hosted a study group tasked with developing sequence, function, and metadata annotation standards for viral genomes. This report describes the issues involved in viral genome annotation and reviews policy recommendations presented at the NCBI Annotation Workshop.
Keywords: virus; genome; annotation virus; genome; annotation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Brister, J.R.; Bao, Y.; Kuiken, C.; Lefkowitz, E.J.; Mercier, P.L.; Leplae, R.; Madupu, R.; Scheuermann, R.H.; Schobel, S.; Seto, D.; Shrivastava, S.; Sterk, P.; Zeng, Q.; Klimke, W.; Tatusova, T. Towards Viral Genome Annotation Standards, Report from the 2010 NCBI Annotation Workshop. Viruses 2010, 2, 2258-2268.

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