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Viruses
Volume 17
Issue 6
10.3390/v17060808
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action

by
Patrícia Mariano Cruz Pereira
1,2,
Andréa de Cássia Rodrigues Silva
3,
Karen Miyuki Asano
3,
Adriana da Costa Neves
4,
Juliana Mozer Sciani
2,5,
Daniel Carvalho Pimenta
1,2,6,* and
Hugo Vigerelli
1,2,7
1
Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo 05503-900, SP, Brazil
2
Programa de Pós-graduação em Toxinologia, Butantan Institute, São Paulo 05503-900, SP, Brazil
3
Laboratory of Rabies Diagnostic, Serology, Pasteur Institute, São Paulo 01311-000, SP, Brazil
4
Laboratory of Genetics, Butantan Institute, São Paulo 05503-900, SP, Brazil
5
Laboratory of Natural Products, Bragança Paulista 12916-900, SP, Brazil
6
Laboratory of Ecology and Evolution (LEEV), Butantan Institute, São Paulo 05503-900, SP, Brazil
7
Centre of Excellence in New Target Discovery (CENTD), Butantan Institute, São Paulo 05503-900, SP, Brazil
*
Author to whom correspondence should be addressed.
Viruses 2025, 17(6), 808; https://doi.org/10.3390/v17060808
Submission received: 15 April 2025 / Revised: 29 May 2025 / Accepted: 29 May 2025 / Published: 31 May 2025
(This article belongs to the Special Issue Rabies Virus: Treatment and Prevention)
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Abstract

Molecules from animals or plant species have been investigated with the aim of treating diseases of epidemiological importance, such as rabies, which is a viral, acute, and infectious disease with approximately 100% lethality. Rabies has been one of the main causes of death in humans concerning infectious diseases. This work investigated the action and preliminary mechanisms of the alkaloid bufotenine in an in vivo model with the rabies virus. A wild-type virus was titrated and injected into mice for the determination of DL50 in the presence or absence of bufotenine. The results reveal that bufotenine has possible action in modulating the immune response of the studied host, suggesting interference in delaying symptom manifestation. Regarding the histological analysis of the CNS of the animals, bufotenine possibly prevented the presence of mononuclear cell inflammatory infiltrate in the meninx’s region compared to the positive control and possibly contributed to reducing neuronal degeneration. The use of the bufotenine extracted from the seed of white angico, a plant representative of Brazilian flora, contributed to antiviral activity with effects on the immunological aspects of the host infected by the rabies virus.
Keywords: rabies virus 1; alkaloid 2; bufotenine 3; immune system; antiviral rabies virus 1; alkaloid 2; bufotenine 3; immune system; antiviral
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MDPI and ACS Style

Pereira, P.M.C.; Silva, A.d.C.R.; Asano, K.M.; da Costa Neves, A.; Sciani, J.M.; Pimenta, D.C.; Vigerelli, H. An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action. Viruses 2025, 17, 808. https://doi.org/10.3390/v17060808

AMA Style

Pereira PMC, Silva AdCR, Asano KM, da Costa Neves A, Sciani JM, Pimenta DC, Vigerelli H. An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action. Viruses. 2025; 17(6):808. https://doi.org/10.3390/v17060808

Chicago/Turabian Style

Pereira, Patrícia Mariano Cruz, Andréa de Cássia Rodrigues Silva, Karen Miyuki Asano, Adriana da Costa Neves, Juliana Mozer Sciani, Daniel Carvalho Pimenta, and Hugo Vigerelli. 2025. "An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action" Viruses 17, no. 6: 808. https://doi.org/10.3390/v17060808

APA Style

Pereira, P. M. C., Silva, A. d. C. R., Asano, K. M., da Costa Neves, A., Sciani, J. M., Pimenta, D. C., & Vigerelli, H. (2025). An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action. Viruses, 17(6), 808. https://doi.org/10.3390/v17060808

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