Next Article in Journal
Long-Term Outcomes of Ledipasvir/Sofosbuvir Treatment in Hepatitis C: Viral Suppression, Hepatocellular Carcinoma, and Mortality in Mongolia
Previous Article in Journal
Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 17
Issue 6
10.3390/v17060742
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Molecular Mechanisms of Cell-to-Cell Transmission in Human Herpesviruses

by
Liyuan Yan
1,2,3,4,5,
Jing Guo
1,2,3,4,
Yinan Zhong
5,
Jiangbo Wei
6 and
Zejun Wang
1,2,3,4,*
1
Wuhan Institute of Biological Products Co., Ltd., No. 1 Huangjin Industrial Park Road, Wuhan 430207, China
2
National Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China
3
National Key Laboratory for Novel Vaccines Research and Development of Emerging Infectious Diseases, 430207 Wuhan, China
4
Hubei Provincial Vaccine Technology Innovation Center, Wuhan 430207, China
5
Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China
6
Weijiangbo Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
*
Author to whom correspondence should be addressed.
Viruses 2025, 17(6), 742; https://doi.org/10.3390/v17060742
Submission received: 5 March 2025 / Revised: 26 April 2025 / Accepted: 19 May 2025 / Published: 22 May 2025
(This article belongs to the Section Human Virology and Viral Diseases)
Versions Notes

Abstract

Members of the family Orthoherpesviridae employs two distinct transmission modes: free virion release and cell-to-cell transmission. The latter enables immune evasion through multiple mechanisms, facilitating infections in skin, mucosa, and neural tissues. This review synthesizes current knowledge on human herpesvirus cell-to-cell transmission mechanisms, including syncytium formation, tight junction exploitation, exosomal transfer, and tunneling nanotube utilization. We analyze how these strategies enhance infection efficiency, evade immune surveillance, and augment pathogenicity. Furthermore, we discuss recent intervention strategies targeting cell-to-cell transmission, including the development of monoclonal antibodies, antiviral drugs, and vaccines. These in
Keywords: human herpesvirus; cell-to-cell transmission; syncytium; tight junction; exosomes; tunneling nanotubes; envelope glycoproteins human herpesvirus; cell-to-cell transmission; syncytium; tight junction; exosomes; tunneling nanotubes; envelope glycoproteins

Share and Cite

MDPI and ACS Style

Yan, L.; Guo, J.; Zhong, Y.; Wei, J.; Wang, Z. Molecular Mechanisms of Cell-to-Cell Transmission in Human Herpesviruses. Viruses 2025, 17, 742. https://doi.org/10.3390/v17060742

AMA Style

Yan L, Guo J, Zhong Y, Wei J, Wang Z. Molecular Mechanisms of Cell-to-Cell Transmission in Human Herpesviruses. Viruses. 2025; 17(6):742. https://doi.org/10.3390/v17060742

Chicago/Turabian Style

Yan, Liyuan, Jing Guo, Yinan Zhong, Jiangbo Wei, and Zejun Wang. 2025. "Molecular Mechanisms of Cell-to-Cell Transmission in Human Herpesviruses" Viruses 17, no. 6: 742. https://doi.org/10.3390/v17060742

APA Style

Yan, L., Guo, J., Zhong, Y., Wei, J., & Wang, Z. (2025). Molecular Mechanisms of Cell-to-Cell Transmission in Human Herpesviruses. Viruses, 17(6), 742. https://doi.org/10.3390/v17060742

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop