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Volume 17
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10.3390/v17010011
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Article

Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections

by
Jennifer Molle
1,†,
Sarah Duponchel
1,†,
Jennifer Rieusset
2,
Michel Ovize
2,
Alexander V. Ivanov
3,
Fabien Zoulim
1 and
Birke Bartosch
1,*
1
INSERM U1052, CNRS UMR5286, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon Hepatology Institute (IHU Everest), 69003 Lyon, France
2
CarMeN Laboratory, INSERM U1060, INRA U1397, Lyon Hepatology Institute, 69007 Lyon, France
3
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2025, 17(1), 11; https://doi.org/10.3390/v17010011
Submission received: 6 June 2024 / Revised: 19 December 2024 / Accepted: 21 December 2024 / Published: 25 December 2024
(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
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Abstract

Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C. Cyps are a group of enzymes with peptidyl-prolyl isomerase activity (PPIase), known to be required for replication of diverse viruses including hepatitis B and C viruses (HBV and HCV). Amongst the Cyp family, the molecular mechanisms underlying the antiviral effects of CypA have been investigated in detail, but potential roles of other Cyps are less well studied in the context of viral hepatitis. Furthermore, most studies investigating the role of Cyps in viral hepatitis did not investigate the potential therapeutic effects of their inhibition in already-established infections but have rather been performed in the context of neo-infections. Here, we investigated the effects of genetically silencing Cyps on persistent HCV and HBV infections. We confirm antiviral effects of CypA and CypD knock down and demonstrate novel roles for CypG and CypH in HCV replication. We show, furthermore, that CypA silencing has a modest but reproducible impact on persistent HBV infections in cultured human hepatocytes.
Keywords: hepatitis virus; cyclophilin; liver; anti-viral treatment hepatitis virus; cyclophilin; liver; anti-viral treatment

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MDPI and ACS Style

Molle, J.; Duponchel, S.; Rieusset, J.; Ovize, M.; Ivanov, A.V.; Zoulim, F.; Bartosch, B. Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections. Viruses 2025, 17, 11. https://doi.org/10.3390/v17010011

AMA Style

Molle J, Duponchel S, Rieusset J, Ovize M, Ivanov AV, Zoulim F, Bartosch B. Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections. Viruses. 2025; 17(1):11. https://doi.org/10.3390/v17010011

Chicago/Turabian Style

Molle, Jennifer, Sarah Duponchel, Jennifer Rieusset, Michel Ovize, Alexander V. Ivanov, Fabien Zoulim, and Birke Bartosch. 2025. "Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections" Viruses 17, no. 1: 11. https://doi.org/10.3390/v17010011

APA Style

Molle, J., Duponchel, S., Rieusset, J., Ovize, M., Ivanov, A. V., Zoulim, F., & Bartosch, B. (2025). Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections. Viruses, 17(1), 11. https://doi.org/10.3390/v17010011

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