Pemphigus and Bullous Pemphigoid Following COVID-19 Vaccination: A Systematic Review
Abstract
:1. Introduction
2. Methods
2.1. Study Selection
2.2. Risk of Bias Selection
3. Result
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Authors | Number of Cases | Clinical Manifestations | Patient (Age/Sex) | COVID-19 Vaccination, Vaccination Dose | Days to Onset the Symptoms | New Onset or Recurrence |
---|---|---|---|---|---|---|
Shakoei et al. [3] | 4 | PV | 28, F | Sinopharm First dose | 14 | Recurrence |
PV | 30, F | Sinopharm First dose | 16 | New onset | ||
BP | 85, F | Sinopharm First dose | 20 | New onset | ||
BP | 91, M | Sinopharm First dose | 19 | New onset | ||
Rasner et al. [4] | 3 | BP | 88, M | Pfizer/BioNTech Second dose | 1 | Recurrence |
BP | 69, M | Moderna Second dose | 14 | Recurrence | ||
PF | 50, F | Pfizer/BioNTech First dose | 7 | Recurrence | ||
Baffa et al. [6] | 1 | BP | 91, F | Pfizer/BioNTech Second dose | 10 | New onset |
Calabria et al. [7] | 1 | Oral mucous membrane pemphigoid | 72, F | Pfizer/BioNTech Third dose | 9 | New onset |
Yamamoto et al. [8] | 1 | BP | 72, M | Pfizer/BioNTech Second dose | Unspecified | New onset |
Sun et al. [9] | 1 | BP | 79, F | Pfizer/BioNTech Second dose | 3 | New onset |
Dell’Antonia et al. [10] | 1 | BP | 83, M | Pfizer/BioNTech First dose | 7 | New onset |
Martora et al. [11] | 4 | BP | 60, M | Pfizer/BioNTech second dose | 7 | Recurrence |
74, M | Pfizer/BioNTech second dose | 5 | Recurrence | |||
78, M | Pfizer/BioNTech second dose | 8 | Recurrence | |||
80, F | Moderna First dose | 6 | Recurrence | |||
Corrá et al. [12] | 5 | PV | 61, F | Pfizer/BioNTech Third dose | 3 | New onset |
PF | 80. M | Pfizer/BioNTech Third dose | 17 | New onset | ||
PF | 66, F | Pfizer/BioNTech Second dose | 28 | New onset | ||
PV | 73, F | Pfizer/BioNTech Third dose | 28 | New onset | ||
PV | 63, F | AstraZeneca First dose | 28 | New onset | ||
Cowan et al. [13] | 10 | BP: 7 | Medium age: 75.1 Sex: F:2 M: 5 | Pfizer/BioNTech: 3 Unspecified dose:3 AstraZeneca:4 Second dose:4 | Medium time: 55.4 | New onset: 4 Recurrence: 3 |
Pemphigus: 3 | Medium age:51.3 Sex: F: 2 M: 1 | Pfizer/BioNTech:3 Unspecified dose:3 | Medium time: 37.6 | New onset: 1 Recurrence: 2 | ||
Diab et al. [14] | 4 | BP | 70, F | Sinopharm First dose | 20 | New onset |
PF | 30, F | Sinopharm Second dose | 14 | New onset | ||
BP | 77, F | Sinopharm Second dose | 30 | New onset | ||
PV | 45, M | BIv1-CoViran Second dose | 20 | New onset | ||
Maronese et al. [15] | 21 | BP | F: 9 M: 12, Medium age: 82 | Pfizer/BioNTech: 17 AstraZeneca: 2 Moderna: 2 First dose: 8 Second dose: 13 | Medium time: Unspecified | Unspecified |
Rouatbi et al. [16] | 2 | PF | 70, M | Pfizer/BioNtech First dose | 7 | New onset |
48, M | AstraZeneca First dose | 5 | New onset | |||
Young et al. [17] | 1 | BP | 68, M | Pfizer BioNTech First dose | 3 | New onset |
Bailly-Caillé [18] | 1 | anti-p200 BP | 74, M | Moderna Second dose | 2 | New onset |
Knechtl et al. [19] | 1 | PV | 89, M | Pfizer BioNTech second dose | 30 | New onset |
Pauluzzi et al. [20] | 1 | BP | 46, M | Pfizer/BioNTech first dose | 15 | New onset |
Avallone et al. [21] | 1 | PV | 46, M | Pfizer/BioNTech First dose | 5 | Recurrence |
Damiani et al. [22] | 5 | BP | 63, F | Moderna First dose | 3 | Recurrence |
PV | 40, M | Moderna first dose | 3 | Recurrence | ||
BP | 84, M | Moderna first dose | 14 | Recurrence | ||
BP | 82, F | Pfizer/BioNTech First dose | 3 | Recurrence | ||
PV | 80, M | Pfizer/BioNTech First dose | 3 | Recurrence | ||
Hung et al. [23] | 1 | BP | 39, M | Moderna first dose | 30 | New onset |
Ligrone et al. [24] | 1 | PV | 56, F | Moderna Third dose | 5 | Recurrence |
Lua et al. [25] | 1 | PF | 83, M | Pfizer/BioNTech Second dose | 2 | New onset |
Hali et al. [26] | 5 | BP | 51, M | AstraZeneca Second dose | 7 | New onset |
BP | 54, F | AstraZeneca First dose | 3 | New onset | ||
BP | 68, M | AstraZeneca Second dose | 7 | New onset | ||
PF | 50, F | Pfizer/BioNTech Second dose | 15 | New onset | ||
PV | 58, F | Pfizer/BioNTech First dose | 30 | New onset | ||
Hinterseher et al. [27] | 4 | PV: 1 | 36, F | Pfizer/BioNTech Third dose | 7 | Recurrence |
BP: 3 | 66, M | Pfizer/BioNTech First dose | 21 | New onset | ||
67, M | AstraZeneca First dose | 7 | Recurrence | |||
61, F | Pfizer/BioNTech Third dose | Unspecified | Recurrence | |||
Schmidt et al. [28] | 1 | BP | 84, F | Moderna first dose | Unspecified | New onset |
Pérez-López et al. [29] | 1 | BP | 78, F | Pfizer/BioNTech First dose | 3 | New onset |
Alshammari et al. [30] | 1 | BP | 78, M | Pfizer/BioNTech Second dose | 1 | New onset |
Desai et al. [31] | 1 | BP | 73, F | Moderna Second dose | 1 | New onset |
Agharbi et al. [32] | 1 | BP | 77, M | AstraZeneca First dose | 1 | New onset |
Aryanian et al. [33] | 1 | PV | 43, M | AstraZeneca Second dose | 2 | New onset |
Hatami et al. [34] | 2 | PV | 34, M | AstraZeneca Unspecified dose | Unspecified | New onset |
PV | 61, M | AstraZeneca Unspecified dose | 7 | Recurrence | ||
Pham et al. [35] | 2 | PF | 53, F | AstraZeneca Fourth dose | 21 | New onset |
PF | 30, F | Moderna Second dose | 60 | New onset | ||
Bostan et al. [36] | 1 | BP | 67, M | Unspecified First dose | 35 | New onset |
Maronese et al. [37] | 3 | BP | 67, M | Pfizer/BioNTech First dose | Unspecified | New onset |
BP | 84, F | Pfizer/BioNTech First dose | Unspecified | New onset | ||
BP | 86, M | Pfizer/BioNTech First dose | Unspecified | New onset | ||
Solimani et al. [38] | 1 | PV | 40, F | Pfizer/BioNTech First dose | 5 | New onset |
Singh et al. [39] | 1 | PV | 40, M | Covishield Second dose | 7 | New onset |
Koutlas et al. [40] | 1 | PV | 60, M | Moderna Second dose | 7 | New onset |
Thongprasom et al. [41] | 1 | Oral pemphigus | 38, F | AstraZeneca First dose | 7 | New onset |
Shanshal [42] | 1 | Dyshidrosiform BP | 90, F | Pfizer/BioNTech First dose | 7 | New onset |
Corrá et al. [12] | 5 | PV | 61, F | Pfizer/BioNTech Third dose | 3 | New onset |
PF | 80, M | Pfizer/BioNTech Third dose | 17 | New onset | ||
PF | 66, F | Pfizer/BioNTech Second dose | 28 | New onset | ||
PV | 73, F | Pfizer/BioNTech Third dose | 28 | New onset | ||
PV | 63, F | AstraZeneca First dose | 28 | New onset | ||
Alami et al. [43] | 1 | PF | 44, M | Sinopharm First dose | 7 | New onset |
Lansang et al. [44] | 1 | IgA pemphigus | 64, M | Moderna Second dose | 20 | New onset |
eWan et al. [45] | 2 | BP | 50, F | Pfizer/BioNTech Second dose | 14 | New onset |
BP | 82, M | Pfizer/BioNTech Second dose | 3 | New onset | ||
Afacan et al. [46] | 7 | BP | Medium Age:75.2 F: 5 M: 2 | CoronaVac:7 First dose: 1 Second dose: 4 Third dose: 2 | Medium time: 18.7 | New onset: 4 Recurrence: 3 |
Matsumoto et al. [47] | 1 | PF | 73, M | Unspecified First dose | 22 | New onset |
Rungraungrayabkul et al. [48] | 1 | Oral mucous membrane pemphigoid | 74, F | Pfizer/BioNTech First dose | 21 | New onset |
Pourani et al. [49] | 1 | PF | 75, M | Sinopharm Third dose | 14 | New onset |
Yıldırıcı et al. [50] | 1 | PF | 65, M | Pfizer/BioNTech First dose | 30 | New onset |
Bardazzi et al. [51] | 4 | BP | 76, F | Pfizer/BioNTech Third dose | 12 | New onset |
BP | 79, M | Pfizer/BioNTech Third dose | 9 | New onset | ||
BP | 57, F | Moderna Third dose | 7 | Recurrence | ||
BP | 62, M | Pfizer/BioNTech Third dose | 7 | Recurrence | ||
Mustin et al. [52] | 1 | Pemphigoid Gestationis | 36, F | Pfizer/BioNTech Second dose | 10 | New onset |
Gui et al. [53] | 2 | Pemphigus vegetans | 25, M | Pfizer/BioNTech Second dose | 30 | New onset |
PF | 67, F | Moderna Second dose | 14 | New onset | ||
Zou et al. [54] | 3 | PV | 60, M | Moderna Second dose | 7 | New onset |
PV | 40, F | Pfizer/BioNTech First dose | 5 | New onset | ||
PV | 38, F | AstraZeneca First dose | 7 | New onset | ||
Reis et al. [55] | 1 | PF | 35, F | Pfizer/BioNTech Second dose | 14 | New onset |
Akoglu [56] | 3 | PV | 69, F | Unspecified Second dose | 7 | New onset |
PV | 58, F | Unspecified Seconde dose | Unspecified | Recurrence | ||
PV | 31, F | Pfizer/BioNTech Second dose | 7 | Recurrence | ||
Khalayli et al. [57] | 1 | PV | 50, F | Unspecified Second dose | 7 | New onset |
Norimatsu et al. [58] | 1 | PV | 86, M | Pfizer/BioNTech Second dose | 1 | New onset |
Almasi-Nasrabadi et al. [59] | 1 | PF | 62, F | AstraZeneca First dose | 7 | New onset |
Falcinelli et al. [60] | 1 | Pemphigus erythematosus | 63, F | Pfizer/BioNTech Second dose | 2 | New onset |
Ong et al. [61] | 1 | PV | 46, F | Moderna First dose | 7 | Recurrence |
Saffarian et al. [62] | 1 | PV | 76, F | Sinopharm Second dose | 30 | New onset |
Gambichler et al. [63] | 2 | BP | 80, M | Pfizer/BioNTech First dose | 7 | New onset |
BP | 89, M | Pfizer/BioNTech First dose | 2 | New onset | ||
Agharbi et al. [64] | 1 | PV | 72, M | Pfizer/BioNTech Second dose | 7 | New onset |
Number of Patients (n = 83) | |
---|---|
Sex | |
Male | 46 (55.4%) |
Female | 37 (44.6%) |
Mean Age (SD) | 72 ± 12.7 |
Clinical Manifestations | |
BP | 78 (94%) |
Others | 5 (6%) |
Days to symptom onset (SD) | 11 ± 10.8 |
New onset diagnosis | 43 (51.8%) |
Recurrence | 19 (22.9%) |
Unspecified | 21 (25.3%) |
Type of COVID-19 vaccination | |
BNT162b2 (Pfizer-BioNTech) | 49 (59%) |
mRNA-1273 (Moderna) | 11 (13.3%) |
ChAdOx1 nCoV-19 AZD1222 (AstraZeneca) | 11 (13.3%) |
BBIBP-CorV (Sinopharm) | 4 (4.8%) |
CoronaVac (Sinovac) | 7 (8.4%) |
Unspecified | 1 (1.2%) |
Vaccination dose | |
1st dose | 34 (41%) |
2nd dose | 38 (45.8%) |
3rd dose | 8 (9.6%) |
Unspecified | 3 (3.6%) |
Number of Patients (n = 59) | |
---|---|
Sex | |
Male | 25 (42.4%) |
Female | 34 (57.6%) |
Mean Age (SD) | 55 ± 16.6 |
Clinical Manifestations | |
PV | 33 (55.9%) |
PF | 19 (32.2%) |
Others | 7 (11.9%) |
Days to symptom onset (SD) | 14 ± 11.7 |
New onset diagnosis | 46 (78%) |
Recurrence | 13 (22%) |
Type of COVID-19 vaccination | |
BNT162b2 (Pfizer-BioNTech) | 29 (49.2%) |
mRNA-1273 (Moderna) | 8 (13.5%) |
ChAdOx1 nCoV-19 AZD1222 (AstraZeneca) | 10 (16.9%) |
ChAdOx1 nCoV-19 (Covishield) | 1 (1.7%) |
BIv1-CoViran | 1 (1.7%) |
BBIBP-CorV (Sinopharm) | 6 (10.2%) |
Unspecified | 4 (6.8%) |
Vaccination dose | |
1st dose | 20 (33.9%) |
2nd dose | 24 (40.7%) |
3rd dose | 9 (15.2%) |
4th dose | 1 (1.7%) |
Unspecified | 5 (8.5%) |
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Martora, F.; Battista, T.; Potestio, L.; Napolitano, M.; Patruno, C.; Megna, M.; D’Agostino, M. Pemphigus and Bullous Pemphigoid Following COVID-19 Vaccination: A Systematic Review. Viruses 2024, 16, 1896. https://doi.org/10.3390/v16121896
Martora F, Battista T, Potestio L, Napolitano M, Patruno C, Megna M, D’Agostino M. Pemphigus and Bullous Pemphigoid Following COVID-19 Vaccination: A Systematic Review. Viruses. 2024; 16(12):1896. https://doi.org/10.3390/v16121896
Chicago/Turabian StyleMartora, Fabrizio, Teresa Battista, Luca Potestio, Maddalena Napolitano, Cataldo Patruno, Matteo Megna, and Michela D’Agostino. 2024. "Pemphigus and Bullous Pemphigoid Following COVID-19 Vaccination: A Systematic Review" Viruses 16, no. 12: 1896. https://doi.org/10.3390/v16121896
APA StyleMartora, F., Battista, T., Potestio, L., Napolitano, M., Patruno, C., Megna, M., & D’Agostino, M. (2024). Pemphigus and Bullous Pemphigoid Following COVID-19 Vaccination: A Systematic Review. Viruses, 16(12), 1896. https://doi.org/10.3390/v16121896