Next Article in Journal
The Discovery of a New Mimivirus Isolate in Association with Virophage-Transpoviron Elements in Brazil Highlights the Main Genomic and Evolutionary Features of This Tripartite System
Previous Article in Journal
Phi 6 Bacteriophage Inactivation by Metal Salts, Metal Powders, and Metal Surfaces
Article

Outcomes of Herpes Simplex Virus Pneumonitis in Critically Ill Patients

1
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei City 10507, Taiwan
2
College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan
3
Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan
4
Ph.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan 33305, Taiwan
5
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 5, Fu-Xing Street, Kweishan, Taoyuan 33305, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Graciela Andrei
Viruses 2022, 14(2), 205; https://doi.org/10.3390/v14020205
Received: 29 December 2021 / Revised: 16 January 2022 / Accepted: 17 January 2022 / Published: 21 January 2022
(This article belongs to the Section Human Virology and Viral Diseases)
Critically ill patients, such as those in intensive care units (ICUs), can develop herpes simplex virus (HSV) pneumonitis. Given the high prevalence of acute respiratory distress syndrome (ARDS) and multiple pre-existing conditions among ICU patients with HSV pneumonitis, factors predicting mortality in this patient population require further investigation. In this retrospective study, the bronchoalveolar lavage or sputum samples of ICU patients were cultured or subjected to a polymerase chain reaction for HSV detection. Univariable and multivariable Cox regressions were conducted for mortality outcomes. The length of hospital stay was plotted against mortality on Kaplan–Meier curves. Among the 119 patients with HSV pneumonitis (age: 65.8 ± 14.9 years), the mortality rate was 61.34% (73 deaths). The mortality rate was significantly lower among patients with diabetes mellitus (odds ratio [OR] 0.12, 95% confidence interval [CI]: 0.02–0.49, p = 0.0009) and significantly higher among patients with ARDS (OR: 4.18, 95% CI: 1.05–17.97, p < 0.0001) or high (≥30) Acute Physiology and Chronic Health Evaluation II scores (OR: 1.08, 95% CI: 1.00–1.18, p = 0.02). Not having diabetes mellitus (DM), developing ARDS, and having a high Acute Physiology and Chronic Health Evaluation II (APACHE II) score were independent predictors of mortality among ICU patients with HSV pneumonitis. View Full-Text
Keywords: herpes simplex virus (HSV) pneumonitis; acute respiratory distress syndrome (ARDS); diabetes mellitus (DM); Acute Physiology and Chronic Health Evaluation II (APACHE II) score herpes simplex virus (HSV) pneumonitis; acute respiratory distress syndrome (ARDS); diabetes mellitus (DM); Acute Physiology and Chronic Health Evaluation II (APACHE II) score
Show Figures

Figure 1

MDPI and ACS Style

Chang, W.-J.; Wang, H.-Y.; Huang, Y.-C.; Lin, C.-Y.; Leu, S.-W.; Hsieh, M.-J.; Huang, C.-C. Outcomes of Herpes Simplex Virus Pneumonitis in Critically Ill Patients. Viruses 2022, 14, 205. https://doi.org/10.3390/v14020205

AMA Style

Chang W-J, Wang H-Y, Huang Y-C, Lin C-Y, Leu S-W, Hsieh M-J, Huang C-C. Outcomes of Herpes Simplex Virus Pneumonitis in Critically Ill Patients. Viruses. 2022; 14(2):205. https://doi.org/10.3390/v14020205

Chicago/Turabian Style

Chang, Wen-Jui, Hsin-Yao Wang, Yu-Chen Huang, Chun-Yu Lin, Shaw-Woei Leu, Meng-Jer Hsieh, and Chung-Chi Huang. 2022. "Outcomes of Herpes Simplex Virus Pneumonitis in Critically Ill Patients" Viruses 14, no. 2: 205. https://doi.org/10.3390/v14020205

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop