Intramuscular [18F]F-FDG Administration for Successful PET Imaging of Golden Hamsters in a Maximum Containment Laboratory Setting
, Anya Crane 1, Jiro Wada 1, Reed F. Johnson 1, Dima A. Hammoud 3 and Ji Hyun Lee 1,4,*
Serge Cammilleri
Round 1
Reviewer 1 Report
very good presentation.
Hui Wang and al. study, the authors analysed :
Intramuscular 18F-FDG administration for successful Pet imaging of Golden Hamsters in a maximum containment laboratory setting.
Pet is becoming an important tool for the investigation for emerging infection diseases in Human but also in animals models.
Pet imaging is performed after intravenous (IV) radiotracer administration, but in small animal intramuscular administration is an interesting challenge.
In this study, the authors analyzed the in vivo biodistribution of major organs such as : brain, lungs,liver,kidneys, myocardium, and spleen, as well as muscle and bone marrow
Although we consider that this study is a solid research work
Reviewer 2 Report
The authors developed and investigated a new method (intramuscular injection of FDG) for hamster PET imaging a maximum security containment to solve a current limitations and drawbacks in a general method (intravascular). The experimental design was well planned and data were well presented. The authors addressed and discussed many issues and current limitation of the new method in a discussion part. This will be of interest for animal research community.
