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by
  • Hui Wang 1,†,
  • Jurgen Seidel 1,† and
  • Ji Hyun Lee 1,4,*
  • et al.

Reviewer 1: Serge Cammilleri Reviewer 2: Keittisak Suwan

Round 1

Reviewer 1 Report

very good presentation.

Hui Wang and al.  study, the authors analysed :

Intramuscular 18F-FDG administration for successful Pet imaging of Golden Hamsters in a maximum containment laboratory setting.

Pet is becoming an important tool for the investigation for emerging infection diseases in Human but also in animals models.

 Pet imaging is performed after intravenous (IV) radiotracer administration, but in small animal intramuscular administration is an interesting challenge.

In this study, the authors analyzed the in vivo biodistribution of  major organs such as : brain, lungs,liver,kidneys, myocardium, and spleen, as well as muscle and bone marrow

Although we consider that this study is a solid research work

Reviewer 2 Report

The authors developed and investigated a new method (intramuscular injection of FDG) for hamster PET imaging a maximum security containment to solve a current limitations and drawbacks in a general method (intravascular). The experimental design was well planned and data were well presented. The authors addressed and discussed many issues and current limitation of the new method in a discussion part. This will be of interest for animal research community.