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Review

On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study

1
Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven, 3000 Leuven, Belgium
2
Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Sorbonne Université, UMR2000, CNRS, 75015 Paris, France
3
Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, 75015 Paris, France
4
WHO Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75015 Paris, France
5
Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, 1050 Bruxelles, Belgium
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Charles E. Rupprecht
Viruses 2021, 13(8), 1628; https://doi.org/10.3390/v13081628
Received: 30 June 2021 / Revised: 6 August 2021 / Accepted: 11 August 2021 / Published: 17 August 2021
(This article belongs to the Special Issue Lyssaviruses and Other Bat Rhabdoviruses)
Rabies is a neglected zoonotic disease which is caused by negative strand RNA-viruses belonging to the genus Lyssavirus. Within this genus, rabies viruses circulate in a diverse set of mammalian reservoir hosts, is present worldwide, and is almost always fatal in non-vaccinated humans. Approximately 59,000 people are still estimated to die from rabies each year, leading to a global initiative to work towards the goal of zero human deaths from dog-mediated rabies by 2030, requiring scientific efforts from different research fields. The past decade has seen a much increased use of phylogeographic and phylodynamic analyses to study the evolution and spread of rabies virus. We here review published studies in these research areas, making a distinction between the geographic resolution associated with the available sequence data. We pay special attention to environmental factors that these studies found to be relevant to the spread of rabies virus. Importantly, we highlight a knowledge gap in terms of applying these methods when all required data were available but not fully exploited. We conclude with an overview of recent methodological developments that have yet to be applied in phylogeographic and phylodynamic analyses of rabies virus. View Full-Text
Keywords: rabies; discrete phylogeography; continuous phylogeography; Bayesian inference; viral spread; environmental factors; pathogen phylodynamics; RABV rabies; discrete phylogeography; continuous phylogeography; Bayesian inference; viral spread; environmental factors; pathogen phylodynamics; RABV
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MDPI and ACS Style

Nahata, K.D.; Bollen, N.; Gill, M.S.; Layan, M.; Bourhy, H.; Dellicour, S.; Baele, G. On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study. Viruses 2021, 13, 1628. https://doi.org/10.3390/v13081628

AMA Style

Nahata KD, Bollen N, Gill MS, Layan M, Bourhy H, Dellicour S, Baele G. On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study. Viruses. 2021; 13(8):1628. https://doi.org/10.3390/v13081628

Chicago/Turabian Style

Nahata, Kanika D., Nena Bollen, Mandev S. Gill, Maylis Layan, Hervé Bourhy, Simon Dellicour, and Guy Baele. 2021. "On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study" Viruses 13, no. 8: 1628. https://doi.org/10.3390/v13081628

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