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Viruses
Volume 13
Issue 8
10.3390/v13081514
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Brief Report

Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy

by
Matteo Castelli
1,†,
Andreina Baj
2,3,†,
Elena Criscuolo
1,
Roberto Ferrarese
1,
Roberta A. Diotti
1,
Michela Sampaolo
4,
Federica Novazzi
2,
Daniela Dalla Gasperina
3,5,
Daniele Focosi
6,
Davide Ferrari
7,
Massimo Locatelli
8,
Massimo Clementi
1,4,
Nicola Clementi
1,4,‡,
Fabrizio Maggi
2,3,*,‡ and
Nicasio Mancini
1,4,*,‡
1
Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy
2
Laboratory of Microbiology, ASST Sette Laghi, 21100 Varese, Italy
3
Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy
4
Laboratory of Microbiology and Virology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
5
Internal Medicine Unit, ASST Sette Laghi, 21100 Varese, Italy
6
North-Western Tuscany Blood Bank, Pisa University Hospital, 56127 Pisa, Italy
7
SCVSA Department, University of Parma, 43121 Parma, Italy
8
Laboratory Medicine Service, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this study.
‡
These authors jointly supervised this work.
Viruses 2021, 13(8), 1514; https://doi.org/10.3390/v13081514
Submission received: 16 June 2021 / Revised: 26 July 2021 / Accepted: 27 July 2021 / Published: 31 July 2021
(This article belongs to the Section Coronaviruses)
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Abstract

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
Keywords: SARS-CoV-2; COVID-19; variant of concern; L452R; R346K; spike SARS-CoV-2; COVID-19; variant of concern; L452R; R346K; spike

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MDPI and ACS Style

Castelli, M.; Baj, A.; Criscuolo, E.; Ferrarese, R.; Diotti, R.A.; Sampaolo, M.; Novazzi, F.; Dalla Gasperina, D.; Focosi, D.; Ferrari, D.; et al. Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy. Viruses 2021, 13, 1514. https://doi.org/10.3390/v13081514

AMA Style

Castelli M, Baj A, Criscuolo E, Ferrarese R, Diotti RA, Sampaolo M, Novazzi F, Dalla Gasperina D, Focosi D, Ferrari D, et al. Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy. Viruses. 2021; 13(8):1514. https://doi.org/10.3390/v13081514

Chicago/Turabian Style

Castelli, Matteo, Andreina Baj, Elena Criscuolo, Roberto Ferrarese, Roberta A. Diotti, Michela Sampaolo, Federica Novazzi, Daniela Dalla Gasperina, Daniele Focosi, Davide Ferrari, and et al. 2021. "Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy" Viruses 13, no. 8: 1514. https://doi.org/10.3390/v13081514

APA Style

Castelli, M., Baj, A., Criscuolo, E., Ferrarese, R., Diotti, R. A., Sampaolo, M., Novazzi, F., Dalla Gasperina, D., Focosi, D., Ferrari, D., Locatelli, M., Clementi, M., Clementi, N., Maggi, F., & Mancini, N. (2021). Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy. Viruses, 13(8), 1514. https://doi.org/10.3390/v13081514

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