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Bacteriophages fEV-1 and fD1 Infect Yersinia pestis

Department of Bacteriology and Immunology, Medicum, Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland
Division of Clinical Microbiology, HUSLAB, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland
Department of Medical Biochemistry, University of Turku, 20520 Turku, Finland
Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, 22184 Lund, Sweden
Author to whom correspondence should be addressed.
Academic Editor: Dann Turner
Viruses 2021, 13(7), 1384;
Received: 23 June 2021 / Revised: 14 July 2021 / Accepted: 14 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue Phage-Host Interactions 2021)
Bacteriophages vB_YpeM_fEV-1 (fEV-1) and vB_YpeM_fD1 (fD1) were isolated from incoming sewage water samples in Turku, Finland, using Yersinia pestis strains EV76 and KIM D27 as enrichment hosts, respectively. Genomic analysis and transmission electron microscopy established that fEV-1 is a novel type of dwarf myovirus, while fD1 is a T4-like myovirus. The genome sizes are 38 and 167 kb, respectively. To date, the morphology and genome sequences of some dwarf myoviruses have been described; however, a proteome characterization such as the one presented here, has currently been lacking for this group of viruses. Notably, fEV-1 is the first dwarf myovirus described for Y. pestis. The host range of fEV-1 was restricted strictly to Y. pestis strains, while that of fD1 also included other members of Enterobacterales such as Escherichia coli and Yersinia pseudotuberculosis. In this study, we present the life cycles, genomes, and proteomes of two Yersinia myoviruses, fEV-1 and fD1. View Full-Text
Keywords: bacteriophage; Yersinia pestis; dwarf myovirus; myovirus; genome; proteome bacteriophage; Yersinia pestis; dwarf myovirus; myovirus; genome; proteome
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MDPI and ACS Style

Skurnik, M.; Jaakkola, S.; Mattinen, L.; von Ossowski, L.; Nawaz, A.; Pajunen, M.I.; Happonen, L.J. Bacteriophages fEV-1 and fD1 Infect Yersinia pestis. Viruses 2021, 13, 1384.

AMA Style

Skurnik M, Jaakkola S, Mattinen L, von Ossowski L, Nawaz A, Pajunen MI, Happonen LJ. Bacteriophages fEV-1 and fD1 Infect Yersinia pestis. Viruses. 2021; 13(7):1384.

Chicago/Turabian Style

Skurnik, Mikael, Salla Jaakkola, Laura Mattinen, Lotta von Ossowski, Ayesha Nawaz, Maria I. Pajunen, and Lotta J. Happonen. 2021. "Bacteriophages fEV-1 and fD1 Infect Yersinia pestis" Viruses 13, no. 7: 1384.

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