Next Article in Journal
Comparative Study of Optical Markers to Assess Bait System Efficiency Concerning Vaccine Release in the Oral Cavity of Dogs
Previous Article in Journal
Detection and Genetic Characterization of Hepatitis B and D Viruses: A Multi-Site Cross-Sectional Study of People Who Use Illicit Drugs in the Amazon Region
Previous Article in Special Issue
Long-Term Longitudinal Evaluation of Six Commercial Immunoassays for the Detection of IgM and IgG Antibodies against SARS CoV-2
Article

Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity

1
Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland
2
Central Laboratory of Central Teaching Hospital, University Clinical Center of Medical University of Warsaw, 02-097 Warsaw, Poland
3
Students Scientific Group of Laboratory Medicine, Department of Laboratory Medicine, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Karin Klingel and Bertram Flehmig
Viruses 2021, 13(7), 1381; https://doi.org/10.3390/v13071381
Received: 9 June 2021 / Revised: 3 July 2021 / Accepted: 7 July 2021 / Published: 15 July 2021
(This article belongs to the Special Issue Viral Markers and the Diagnosis of COVID-19)
Distinguishing between severe and nonsevere COVID-19 to ensure adequate healthcare quality and efficiency is a challenge for the healthcare system. The aim of this study was to assess the usefulness of CBC parameters together with analysis of FLC serum concentration in risk stratification of COVID-19. Materials and methods: CBC was analyzed in 735 COVID ICU, COVID non-ICU, and non-COVID ICU cases. FLC concentration was analyzed in 133 of them. Results: COVID ICU had neutrophils and lymphocytes with the greatest size, granularity, and nucleic acid content. Significant differences in concentrations of κ and λ FLCs were shown between COVID ICU and COVID non-ICU. However, no difference was found in the κ/λ ratio between these groups, and the ratio stayed within the reference value, which indicates the presence of polyclonal FLCs. FLC κ measurement has significant power to distinguish between severe COVID-19 and nonsevere COVID-19 (AUC = 0.7669), with a sensitivity of 86.67% and specificity of 93.33%. The κ coefficients’ odds ratio of 3.0401 was estimated. Conclusion: It can be concluded that the results obtained from the measure of free light immunoglobulin concentration in serum are useful in distinguishing between severe and nonsevere COVID-19. View Full-Text
Keywords: COVID-19; FLC; antibody synthesis lymphocytes COVID-19; FLC; antibody synthesis lymphocytes
Show Figures

Figure 1

MDPI and ACS Style

Małecka-Giełdowska, M.; Fołta, M.; Wiśniewska, A.; Czyżewska, E.; Ciepiela, O. Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity. Viruses 2021, 13, 1381. https://doi.org/10.3390/v13071381

AMA Style

Małecka-Giełdowska M, Fołta M, Wiśniewska A, Czyżewska E, Ciepiela O. Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity. Viruses. 2021; 13(7):1381. https://doi.org/10.3390/v13071381

Chicago/Turabian Style

Małecka-Giełdowska, Milena, Maria Fołta, Agnieszka Wiśniewska, Emilia Czyżewska, and Olga Ciepiela. 2021. "Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity" Viruses 13, no. 7: 1381. https://doi.org/10.3390/v13071381

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop