Next Article in Journal
CpG Methylation Profiles of HIV-1 Proviral DNA in Individuals on ART
Next Article in Special Issue
Herpes Simplex Virus Type 2 Mucin-Like Glycoprotein mgG Promotes Virus Release from the Surface of Infected Cells
Previous Article in Journal
ER Stress, UPR Activation and the Inflammatory Response to Viral Infection
Previous Article in Special Issue
Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells
Review

Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review

by 1,2,†, 1,†, 1,† and 1,3,*
1
Interfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, Germany
2
Faculté de Médecine, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France
3
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Jacques Le Pendu
Viruses 2021, 13(5), 800; https://doi.org/10.3390/v13050800
Received: 14 April 2021 / Revised: 26 April 2021 / Accepted: 26 April 2021 / Published: 29 April 2021
(This article belongs to the Special Issue Glycans in Viral Infection and Immunity)
Viruses are infectious agents that hijack the host cell machinery in order to replicate and generate progeny. Viral infection is initiated by attachment to host cell receptors, and typical viral receptors are cell-surface-borne molecules such as proteins or glycan structures. Sialylated glycans (glycans bearing sialic acids) and glycosaminoglycans (GAGs) represent major classes of carbohydrate receptors and have been implicated in facilitating viral entry for many viruses. As interactions between viruses and sialic acids have been extensively reviewed in the past, this review provides an overview of the current state of structural knowledge about interactions between non-enveloped human viruses and GAGs. We focus here on adeno-associated viruses, human papilloma viruses (HPVs), and polyomaviruses, as at least some structural information about the interactions of these viruses with GAGs is available. We also discuss the multivalent potential for GAG binding, highlighting the importance of charged interactions and positively charged amino acids at the binding sites, and point out challenges that remain in the field. View Full-Text
Keywords: viruses; glycans; glycosaminoglycans; glycovirology; non-enveloped viruses; structural biology viruses; glycans; glycosaminoglycans; glycovirology; non-enveloped viruses; structural biology
Show Figures

Figure 1

MDPI and ACS Style

Sorin, M.N.; Kuhn, J.; Stasiak, A.C.; Stehle, T. Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review. Viruses 2021, 13, 800. https://doi.org/10.3390/v13050800

AMA Style

Sorin MN, Kuhn J, Stasiak AC, Stehle T. Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review. Viruses. 2021; 13(5):800. https://doi.org/10.3390/v13050800

Chicago/Turabian Style

Sorin, Marie N., Jasmin Kuhn, Aleksandra C. Stasiak, and Thilo Stehle. 2021. "Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review" Viruses 13, no. 5: 800. https://doi.org/10.3390/v13050800

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop