Next Article in Journal
Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice
Next Article in Special Issue
Longitudinal Assessment of Lipoprotein(a) Levels in Perinatally HIV-Infected Children and Adolescents
Previous Article in Journal
IgG Antibodies Develop to Spike but Not to the Nucleocapsid Viral Protein in Many Asymptomatic and Light COVID-19 Cases
Article

Neuropsychological and Psychosocial Functioning of Children with Perinatal HIV-Infection in The Netherlands

1
Center of Expertise Innovations in Care, Rotterdam University of Applied Sciences, 3015 EK Rotterdam, The Netherlands
2
Department of Viroscience, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands
3
Department of Pediatrics, Division of Infectious Diseases and Immunology, Erasmus MC University Medical Center-Sophia Children’s Hospital, 3015 GD Rotterdam, The Netherlands
4
Department of Psychosocial Care and Psychology, Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands
5
Department of Child and Adolescent Psychiatry, Erasmus MC University Medical Center, 3015 CN Rotterdam, The Netherlands
6
Research Institute of Child Development and Education, University of Amsterdam, Levvel, 1018 WS Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Dasja Pajkrt
Viruses 2021, 13(10), 1947; https://doi.org/10.3390/v13101947
Received: 24 August 2021 / Revised: 22 September 2021 / Accepted: 23 September 2021 / Published: 28 September 2021
(This article belongs to the Special Issue Long-Term Outcomes of Treated Perinatal HIV Infection)
Advances in antiretroviral treatment improved the life expectancy of perinatally HIV-infected children. However, growing up with HIV provides challenges in daily functioning. This cross-sectional cohort study investigated the neuropsychological and psychosocial functioning of a group of perinatally HIV-infected children in the Netherlands and compared their outcomes with Dutch normative data and outcomes of a control group of uninfected siblings. The children’s functioning was assessed with internationally well-known and standardized questionnaires, using a multi-informant approach, including the perspectives of caregivers, teachers, and school-aged children. In addition, we explored the associations of socio-demographic and medical characteristics of the HIV-infected children with their neuropsychological and psychosocial functioning. Caregivers reported compromised functioning when compared to Dutch normative data for HIV-infected children in the areas of attention, sensory processing, social-emotional functioning, and health-related quality of life. Teachers reported in addition compromised executive functioning for HIV-infected children. A comparison with siblings revealed differences in executive functioning, problems with peers, and general health. The concurrent resemblance between HIV-infected children and siblings regarding problems in other domains implies that social and contextual factors may be of influence. A family-focused approach with special attention to the child’s socio-environmental context and additional attention for siblings is recommended. View Full-Text
Keywords: perinatally HIV-infected children; long-term outcomes; neuropsychological and psychosocial development perinatally HIV-infected children; long-term outcomes; neuropsychological and psychosocial development
Show Figures

Figure 1

MDPI and ACS Style

van Opstal, S.E.M.; Dogterom, E.J.; Wagener, M.N.; Aarsen, F.K.; Miedema, H.S.; Roelofs, P.D.D.M.; van der Knaap, L.C.; Fraaij, P.L.A.; Stol, K.; Rietman, A.B.; van Gorp, E.C.M.; van Rossum, A.M.C.; Utens, E.M.W.J. Neuropsychological and Psychosocial Functioning of Children with Perinatal HIV-Infection in The Netherlands. Viruses 2021, 13, 1947. https://doi.org/10.3390/v13101947

AMA Style

van Opstal SEM, Dogterom EJ, Wagener MN, Aarsen FK, Miedema HS, Roelofs PDDM, van der Knaap LC, Fraaij PLA, Stol K, Rietman AB, van Gorp ECM, van Rossum AMC, Utens EMWJ. Neuropsychological and Psychosocial Functioning of Children with Perinatal HIV-Infection in The Netherlands. Viruses. 2021; 13(10):1947. https://doi.org/10.3390/v13101947

Chicago/Turabian Style

van Opstal, Stefanie E.M., Emma J. Dogterom, Marlies N. Wagener, Femke K. Aarsen, Harald S. Miedema, Pepijn D.D.M. Roelofs, Linda C. van der Knaap, Pieter L.A. Fraaij, Kim Stol, André B. Rietman, Eric C.M. van Gorp, Annemarie M.C. van Rossum, and Elisabeth M.W.J. Utens 2021. "Neuropsychological and Psychosocial Functioning of Children with Perinatal HIV-Infection in The Netherlands" Viruses 13, no. 10: 1947. https://doi.org/10.3390/v13101947

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop