Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro
Abstract
:1. Introduction
2. Materials and Methods
2.1. Aqueous Turmeric Root Extract
2.2. Curcumin-Containing Nutritional Supplement Capsule
2.3. Curcumin
2.4. Cells and Virus
2.5. Neutralization Assay on Vero E6 Cells
2.6. Neutralization Assay via icELISA on Human Calu-3 Cells
2.7. Cell Viability Assay
2.8. Quantitative SARS-CoV-2 RT-PCR
3. Results
3.1. In Vitro Neutralization of SARS-CoV-2
3.2. Effect of Curcumin on SARS-CoV-2 RNA
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Bormann, M.; Alt, M.; Schipper, L.; van de Sand, L.; Le-Trilling, V.T.K.; Rink, L.; Heinen, N.; Madel, R.J.; Otte, M.; Wuensch, K.; Heilingloh, C.S.; Mueller, T.; Dittmer, U.; Elsner, C.; Pfaender, S.; Trilling, M.; Witzke, O.; Krawczyk, A. Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro. Viruses 2021, 13, 1914. https://doi.org/10.3390/v13101914
Bormann M, Alt M, Schipper L, van de Sand L, Le-Trilling VTK, Rink L, Heinen N, Madel RJ, Otte M, Wuensch K, Heilingloh CS, Mueller T, Dittmer U, Elsner C, Pfaender S, Trilling M, Witzke O, Krawczyk A. Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro. Viruses. 2021; 13(10):1914. https://doi.org/10.3390/v13101914
Chicago/Turabian StyleBormann, Maren, Mira Alt, Leonie Schipper, Lukas van de Sand, Vu Thuy Khanh Le-Trilling, Lydia Rink, Natalie Heinen, Rabea Julia Madel, Mona Otte, Korbinian Wuensch, Christiane Silke Heilingloh, Thorsten Mueller, Ulf Dittmer, Carina Elsner, Stephanie Pfaender, Mirko Trilling, Oliver Witzke, and Adalbert Krawczyk. 2021. "Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro" Viruses 13, no. 10: 1914. https://doi.org/10.3390/v13101914