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Volume 13
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10.3390/v13101909
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Article

Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting

by
Yeu-Yang Tseng
1,2,3,
Chih-Ying Kuan
1,
Masaki Mibayashi
4,
Chi-Jene Chen
4,
Peter Palese
4,5,
Randy A. Albrecht
4,6 and
Wei-Li Hsu
1,*
1
Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan
2
WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia
3
Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia
4
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
*
Author to whom correspondence should be addressed.
Viruses 2021, 13(10), 1909; https://doi.org/10.3390/v13101909
Submission received: 26 August 2021 / Revised: 16 September 2021 / Accepted: 17 September 2021 / Published: 23 September 2021
(This article belongs to the Section Animal Viruses)
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Abstract

Influenza A virus nonstructural protein 1 (NS1) plays an important role in evading host innate immunity. NS1 inhibits interferon (IFN) responses via multiple mechanisms, including sequestering dsRNA and suppressing retinoic acid-inducible gene I (RIG-I) signaling by interacting with RIG-I and tripartite motif-containing protein 25 (TRIM25). In the current study, we demonstrated the mitochondrial localization of NS1 at the early stage of influenza virus infection. Since NS1 does not contain mitochondria-targeting signals, we suspected that there is an association between the NS1 and mitochondrial proteins. This hypothesis was tested by demonstrating the interaction of NS1 with mitochondrial antiviral-signaling protein (MAVS) in a RIG-I-independent manner. Importantly, the association with MAVS facilitated the mitochondrial localization of NS1 and thereby significantly impeded MAVS-mediated Type I IFN production.
Keywords: influenza A virus; NS1; MAVS; mitochondria influenza A virus; NS1; MAVS; mitochondria

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MDPI and ACS Style

Tseng, Y.-Y.; Kuan, C.-Y.; Mibayashi, M.; Chen, C.-J.; Palese, P.; Albrecht, R.A.; Hsu, W.-L. Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting. Viruses 2021, 13, 1909. https://doi.org/10.3390/v13101909

AMA Style

Tseng Y-Y, Kuan C-Y, Mibayashi M, Chen C-J, Palese P, Albrecht RA, Hsu W-L. Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting. Viruses. 2021; 13(10):1909. https://doi.org/10.3390/v13101909

Chicago/Turabian Style

Tseng, Yeu-Yang, Chih-Ying Kuan, Masaki Mibayashi, Chi-Jene Chen, Peter Palese, Randy A. Albrecht, and Wei-Li Hsu. 2021. "Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting" Viruses 13, no. 10: 1909. https://doi.org/10.3390/v13101909

APA Style

Tseng, Y.-Y., Kuan, C.-Y., Mibayashi, M., Chen, C.-J., Palese, P., Albrecht, R. A., & Hsu, W.-L. (2021). Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting. Viruses, 13(10), 1909. https://doi.org/10.3390/v13101909

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