Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Nucleic Acid Extraction, Amplification and Sequencing
2.3. Phylogenetic Analyses
2.4. Phylogeographic and Phylodynamic Analyses
2.5. Antiretroviral Drug Resistance Analysis
3. Results
3.1. PR–RT Sequence Analyses
3.2. NFLG Sequence Analyses
3.3. Phylogeographic and Phylodynamic Analyses
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Ethics Statement
References
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Sample | City | Region * | Country of Origin | Year of Diagnosis | Year of Collection | Gender | Age | Transmission Route † | PR–RT GenBank Accession | NFLG GenBank Accession |
---|---|---|---|---|---|---|---|---|---|---|
P1363 | Vitoria | Basque C. | Spain | 2006 | 2010 | M | 64 | Het | MT436238 | - |
P1607 | Vitoria | Basque C. | Brazil | 2007 | 2007 | F | 20 | Trans | MT436239 | - |
P2085 | Vitoria | Basque C. | Spain | 2008 | 2008 | M | 40 | Het | MT559129 | - |
P2782 | San Sebastián | Basque C. | Spain | 2011 | 2011 | M | 38 | Het | MT436240 | - |
P2969 | San Sebastián | Basque C. | Spain | 2011 | 2011 | F | 32 | Het | MT436241 | - |
P3536 | Bilbao | Basque C. | Spain | 2013 | 2013 | M | 70 | Het | MT436242 | MT559130 |
P4439 | Vitoria | Basque C. | Spain | 2016 | 2016 | F | 58 | Het | MT436244 | MN172222 |
P4517 | Vitoria | Basque C. | Spain | 2010 | 2016 | M | 58 | n.a. | MT436245 | - |
P4523 | Bilbao | Basque C. | Spain | 2016 | 2016 | M | 42 | Het | MT436246 | MT559131 ‡ |
P4697 | Vitoria | Basque C. | Spain | 2017 | 2017 | F | 28 | Het | MT436247 | MT559132 |
P4719 | Vitoria | Basque C. | Spain | 2017 | 2017 | M | 44 | Het | MT436248 | - |
P4977 | Vitoria | Basque C. | Spain | 2018 | 2018 | M | 53 | Het | MT436249 | MN172223 |
P5007 | Vitoria | Basque C. | Spain | 2018 | 2018 | M | 35 | Het | MT436250 | MN172224 |
P5236 | Vitoria | Basque C. | Spain | 2019 | 2019 | F | 65 | Het | MT436251 | - |
Z0230 | Zaragoza | Aragon | Spain | 2017 | 2017 | M | 36 | MSM | MT436252 | MN172225 |
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Cañada, J.E.; Delgado, E.; Gil, H.; Sánchez, M.; Benito, S.; García-Bodas, E.; Gómez-González, C.; Canut-Blasco, A.; Portu-Zapirain, J.; Sáez de Adana, E.; et al. Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain. Viruses 2021, 13, 93. https://doi.org/10.3390/v13010093
Cañada JE, Delgado E, Gil H, Sánchez M, Benito S, García-Bodas E, Gómez-González C, Canut-Blasco A, Portu-Zapirain J, Sáez de Adana E, et al. Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain. Viruses. 2021; 13(1):93. https://doi.org/10.3390/v13010093
Chicago/Turabian StyleCañada, Javier E., Elena Delgado, Horacio Gil, Mónica Sánchez, Sonia Benito, Elena García-Bodas, Carmen Gómez-González, Andrés Canut-Blasco, Joseba Portu-Zapirain, Ester Sáez de Adana, and et al. 2021. "Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain" Viruses 13, no. 1: 93. https://doi.org/10.3390/v13010093