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Open AccessArticle

Deletion in the S1 Region of Porcine Epidemic Diarrhea Virus Reduces the Virulence and Influences the Virus-Neutralizing Activity of the Antibody Induced

1
Animal Health Research Institute, Council of Agriculture, Executive Yuan, 376 Chung-Cheng Road, Tansui, New Taipei City 25158, Taiwan
2
School of Veterinary Medicine, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Tohru Suzuki
Viruses 2020, 12(12), 1378; https://doi.org/10.3390/v12121378
Received: 13 October 2020 / Revised: 30 November 2020 / Accepted: 30 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Enteric Viruses in Animals)
Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and a high rate of mortality in suckling pigs. The epidemic of PEDV that occurred after 2013 was caused by non-insertion and deletion of S gene (S-INDEL) PEDV strains. During this epidemic, a variant of the non-S-INDEL PEDV strain with a large deletion of 205 amino acids on the spike gene (5-17-V) was also found to co-exist with a non-S-INDEL PEDV without deletion (5-17-O). Herein, we describe the differences in the complete genome, distribution, virulence, and antigenicity between strain 5-17-O and variant strain 5-17-V. The deletion of 205 amino acids was primarily located in the S1O domain and was associated with milder clinical signs and lower mortality in suckling pigs than those of the 5-17-O strain. The 5-17-V strain-induced antibody did not completely cross-neutralize the 5-17-O strain. In conclusion, the deletion in the S1 region reduces the virulence of PEDV and influences the virus-neutralizing activities of the antibody it induces. View Full-Text
Keywords: PEDV; deletion; spike protein; virulence; neutralizing active PEDV; deletion; spike protein; virulence; neutralizing active
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MDPI and ACS Style

Tsai, K.-J.; Deng, M.-C.; Wang, F.-I.; Tsai, S.-H.; Chang, C.; Chang, C.-Y.; Huang, Y.-L. Deletion in the S1 Region of Porcine Epidemic Diarrhea Virus Reduces the Virulence and Influences the Virus-Neutralizing Activity of the Antibody Induced. Viruses 2020, 12, 1378. https://doi.org/10.3390/v12121378

AMA Style

Tsai K-J, Deng M-C, Wang F-I, Tsai S-H, Chang C, Chang C-Y, Huang Y-L. Deletion in the S1 Region of Porcine Epidemic Diarrhea Virus Reduces the Virulence and Influences the Virus-Neutralizing Activity of the Antibody Induced. Viruses. 2020; 12(12):1378. https://doi.org/10.3390/v12121378

Chicago/Turabian Style

Tsai, Kuo-Jung; Deng, Ming-Chung; Wang, Fun-In; Tsai, Shu-Hui; Chang, Chieh; Chang, Chia-Yi; Huang, Yu-Liang. 2020. "Deletion in the S1 Region of Porcine Epidemic Diarrhea Virus Reduces the Virulence and Influences the Virus-Neutralizing Activity of the Antibody Induced" Viruses 12, no. 12: 1378. https://doi.org/10.3390/v12121378

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