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Open AccessArticle

Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?

1
Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2
Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
3
University Children’s Hospital (UKBB), University of Basel, Spitalstrasse 33, Postfach, 4031 Basel, Switzerland
4
Computational Physiology and Biostatistics, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, Switzerland
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(10), 1175; https://doi.org/10.3390/v12101175
Received: 10 September 2020 / Revised: 13 October 2020 / Accepted: 14 October 2020 / Published: 17 October 2020
(This article belongs to the Special Issue Rhinovirus Infections)
Accurate detection of human respiratory viral infections is highly topical. We investigated how strongly inflammatory biomarkers (FeNO, eosinophils, neutrophils, and cytokines in nasal lavage fluid) and lung function parameters change upon rhinovirus 16 infection, in order to explore their potential use for infection detection. To this end, within a longitudinal cohort study, healthy and mildly asthmatic volunteers were experimentally inoculated with rhinovirus 16, and time series of these parameters/biomarkers were systematically recorded and compared between the pre- and post-infection phases of the study, which lasted two months and one month, respectively. We found that the parameters’/biomarkers’ ability to discriminate between the infected and the uninfected state varied over the observation time period. Consistently over time, the concentration of cytokines, in nasal lavage fluid, showed moderate to very good discrimination performance, thereby qualifying for disease progression monitoring, whereas lung function and FeNO, while quickly and non-invasively measurable using cheap portable devices (e.g., at airports), performed poorly. View Full-Text
Keywords: viral respiratory infections; rhinovirus; detection of viral infections; lung function; inflammatory biomarkers viral respiratory infections; rhinovirus; detection of viral infections; lung function; inflammatory biomarkers
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Sinha, A.; Lutter, R.; Dekker, T.; Dierdorp, B.; J. Sterk, P.; Frey, U.; Delgado-Eckert, E. Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections? Viruses 2020, 12, 1175.

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