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Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020

Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia
Surveillance, Emergency and Research Unit, Ministry of Health, Port Vila, Vanuatu
National Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, Fiji
Laboratoire de Biologie Médicale, Hôpital de Sia, Mata’Utu 98600, Wallis et Futuna
Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 75015 Paris, France
New Caledonia Health Authorities (Direction des Affaires Sanitaires et Sociales-Nouvelle-Calédonie, DASS-NC), Noumea 98800, New Caledonia
WHO Country Liaison Office, Port Vila, Vanuatu
Pacific Community (SPC), Noumea 98800, New Caledonia
Centre Hospitalier Territorial, Microbiology Laboratory, Dumbea-sur-Mer, Dumbea 98835, New Caledonia
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2020, 12(10), 1081;
Received: 4 August 2020 / Revised: 11 September 2020 / Accepted: 14 September 2020 / Published: 25 September 2020
(This article belongs to the Special Issue Viral Molecular Epidemiology)
Dengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016–2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing DENV-1. In this context, epidemiological and molecular evolution data are paramount to decipher the diffusion route of this DENV-2 in the South Pacific region. In the current work, the E gene from 23 DENV-2 serum samples collected in Vanuatu, Fiji, Wallis and Futuna, and New Caledonia was sequenced. Both maximum likelihood and Bayesian phylogenetic analyses were performed. While all DENV-2 strains sequenced belong to the Cosmopolitan genotype, phylogenetic analysis suggests at least three different DENV-2 introductions in the South Pacific between 2017 and 2020. Strains retrieved in these Pacific Islands Countries and Territories (PICTs) in 2017–2020 are phylogenetically related, with strong phylogenetic links between strains retrieved from French PICTs. These phylogenetic data substantiate epidemiological data of the DENV-2 diffusion pattern between these countries. View Full-Text
Keywords: dengue; phylogeny; molecular evolution; Pacific dengue; phylogeny; molecular evolution; Pacific
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MDPI and ACS Style

Inizan, C.; O’Connor, O.; Worwor, G.; Cabemaiwai, T.; Grignon, J.-C.; Girault, D.; Minier, M.; Prot, M.; Ballan, V.; Pakoa, G.J.; Grangeon, J.-P.; Guyant, P.; Lepers, C.; Faktaufon, D.; Sahukhan, A.; Merilles, O.E., Jr.; Gourinat, A.-C.; Simon-Lorière, E.; Dupont-Rouzeyrol, M. Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020. Viruses 2020, 12, 1081.

AMA Style

Inizan C, O’Connor O, Worwor G, Cabemaiwai T, Grignon J-C, Girault D, Minier M, Prot M, Ballan V, Pakoa GJ, Grangeon J-P, Guyant P, Lepers C, Faktaufon D, Sahukhan A, Merilles OE Jr., Gourinat A-C, Simon-Lorière E, Dupont-Rouzeyrol M. Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020. Viruses. 2020; 12(10):1081.

Chicago/Turabian Style

Inizan, Catherine; O’Connor, Olivia; Worwor, George; Cabemaiwai, Talica; Grignon, Jean-Claude; Girault, Dominique; Minier, Marine; Prot, Matthieu; Ballan, Valentine; Pakoa, George J.; Grangeon, Jean-Paul; Guyant, Philippe; Lepers, Christelle; Faktaufon, Daniel; Sahukhan, Aalisha; Merilles, Onofre E., Jr.; Gourinat, Ann-Claire; Simon-Lorière, Etienne; Dupont-Rouzeyrol, Myrielle. 2020. "Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020" Viruses 12, no. 10: 1081.

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