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Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Key laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
College of Science, Sichuan Agricultural University, Ya’an 625014, China
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Present address: Department of Molecular Genetics, Faculty of Science and Engineering, Nijenborgh 7, 9747 AG, University of Groningen, 9713 GZ Groningen, The Netherlands
Viruses 2018, 10(9), 457;
Received: 15 July 2018 / Revised: 22 August 2018 / Accepted: 23 August 2018 / Published: 27 August 2018
(This article belongs to the Section Antivirals & Vaccines)
Pseudorabies virus (PRV) is one of the most important pathogens of swine, resulting in devastating disease and economic losses worldwide. Nevertheless, there are currently no antiviral drugs available for PRV infection. Resveratrol (Res) was identified to exert its antiviral activity by inhibiting the PRV replication in preliminary investigations. In our previous study, we found that Res has anti-PRV activity in vitro. Here, we show that Res can effectively reduce the mortality and increase the growth performance of PRV-infected piglets. After Res treatment, the viral loads significantly (p < 0.001) decreased. Pathological symptoms, particularly inflammation in the brain caused by PRV infection, were significantly (p < 0.001) relieved by the effects of Res. In Res-treated groups, higher levels of cytokines in serum, including interferon gama, interleukin 12, tumor necrosis factor-alpha and interferon alpha were observed at 7 days post infection. These results indicated that Res possesses potent inhibitory activity against PRV-infection through inhibiting viral reproduction, alleviating PRV-induced inflammation and enhancing animal immunity, suggesting that Res is expected to be a new alternative control measure for PRV infection. View Full-Text
Keywords: antiviral activity; resveratrol; virulent pseudorabies virus; piglets antiviral activity; resveratrol; virulent pseudorabies virus; piglets
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Zhao, X.; Tong, W.; Song, X.; Jia, R.; Li, L.; Zou, Y.; He, C.; Liang, X.; Lv, C.; Jing, B.; Lin, J.; Yin, L.; Ye, G.; Yue, G.; Wang, Y.; Yin, Z. Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus. Viruses 2018, 10, 457.

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