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Viruses 2018, 10(6), 294; https://doi.org/10.3390/v10060294

The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

1
Laboratory of Molecular RNA Virology & Antiviral Strategies, Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University Health System, 5 Science Drive 2, National University of Singapore, Singapore 117597, Singapore
2
Institute of Molecular & Cell Biology, Agency for Science, Technology & Research (A*STAR), 61 Biopolis Drive, Proteos #06-05, Singapore 138673, Singapore
*
Author to whom correspondence should be addressed.
Received: 29 March 2018 / Revised: 13 May 2018 / Accepted: 28 May 2018 / Published: 30 May 2018
(This article belongs to the Special Issue Advances in Alphavirus Research)
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Abstract

Chikungunya virus (CHIKV) has re-emerged as one of the many medically important arboviruses that have spread rampantly across the world in the past decade. Infected patients come down with acute fever and rashes, and a portion of them suffer from both acute and chronic arthralgia. Currently, there are no targeted therapeutics against this debilitating virus. One approach to develop potential therapeutics is by understanding the viral-host interactions. However, to date, there has been limited research undertaken in this area. In this review, we attempt to briefly describe and update the functions of the different CHIKV proteins and their respective interacting host partners. In addition, we also survey the literature for other reported host factors and pathways involved during CHIKV infection. There is a pressing need for an in-depth understanding of the interaction between the host environment and CHIKV in order to generate potential therapeutics. View Full-Text
Keywords: chikungunya virus; host factors; potential therapeutics; interactions; antiviral; viral structural proteins; viral non-structural proteins chikungunya virus; host factors; potential therapeutics; interactions; antiviral; viral structural proteins; viral non-structural proteins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wong, K.Z.; Chu, J.J.H. The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies. Viruses 2018, 10, 294.

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