Next Article in Journal
Vitamin E Supplementation Ameliorates Newcastle Disease Virus-Induced Oxidative Stress and Alleviates Tissue Damage in the Brains of Chickens
Next Article in Special Issue
Rapid Identification of Intact Staphylococcal Bacteriophages Using Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry
Previous Article in Journal
Rapid CRISPR/Cas9-Mediated Cloning of Full-Length Epstein-Barr Virus Genomes from Latently Infected Cells
Previous Article in Special Issue
In Vitro Characteristics of Phages to Guide ‘Real Life’ Phage Therapy Suitability
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessBrief Report
Viruses 2018, 10(4), 172; https://doi.org/10.3390/v10040172

Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo

1
Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
2
National Institute for Biomedical Research, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo
3
Department of Microbiology, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo
4
KU Leuven, Laboratory for Gene Technology, B-3000 Leuven, Belgium
5
Centre of Microbial and Plant Genetics, KU Leuven, B-3000 Leuven, Belgium
6
Department of Clinical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
7
Department of Microbiology and Immunology, KU Leuven, B-3000 Leuven, Belgium
8
Department of Biomedical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
9
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
10
Department of Biological Sciences, Cork Institute of Technology, Cork T12 P928, Ireland
11
Institute of Molecular Biology, 0014 Yerevan, Armenia
12
Center for Infectious Diseases ID4C, Queen Astrid Military Hospital, B-1120 Brussels, Belgium
13
Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, B-1120 Brussels, Belgium
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 March 2018 / Revised: 31 March 2018 / Accepted: 2 April 2018 / Published: 3 April 2018
(This article belongs to the Special Issue Hurdles for Phage Therapy (PT) to Become a Reality)
Full-Text   |   PDF [4060 KB, uploaded 3 May 2018]   |  

Abstract

Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general. View Full-Text
Keywords: typhoid fever; Salmonella Typhi; extended-spectrum beta lactamases (ESBL); Democratic Republic of the Congo; bacteriophages typhoid fever; Salmonella Typhi; extended-spectrum beta lactamases (ESBL); Democratic Republic of the Congo; bacteriophages
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kakabadze, E.; Makalatia, K.; Grdzelishvili, N.; Bakuradze, N.; Goderdzishvili, M.; Kusradze, I.; Phoba, M.-F.; Lunguya, O.; Lood, C.; Lavigne, R.; Jacobs, J.; Deborggraeve, S.; De Block, T.; Van Puyvelde, S.; Lee, D.; Coffey, A.; Sedrakyan, A.; Soentjens, P.; De Vos, D.; Pirnay, J.-P.; Chanishvili, N. Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo. Viruses 2018, 10, 172.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top