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Viruses 2018, 10(3), 104; https://doi.org/10.3390/v10030104

Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue

1
Imunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, Brazil
2
Santa Casa de Misericórdia de Santo Antônio do Monte, Santo Antônio do Monte 35560-000, Brazil
3
Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou, Belo Horizonte 30190-002, Brazil
*
Authors to whom correspondence should be addressed.
Received: 2 February 2018 / Revised: 23 February 2018 / Accepted: 25 February 2018 / Published: 28 February 2018
(This article belongs to the Special Issue 6th Pan-American Dengue Research Network Meeting)
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Abstract

The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage. View Full-Text
Keywords: Dengue virus; eicosanoids; cyclooxygenase-2; 5-lipoxygenase; lipid bodies Dengue virus; eicosanoids; cyclooxygenase-2; 5-lipoxygenase; lipid bodies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Oliveira, E.S.; Colombarolli, S.G.; Nascimento, C.S.; Batista, I.C.A.; Ferreira, J.G.G.; Alvarenga, D.L.R.; de Sousa, L.O.B.; Assis, R.R.; Rocha, M.N.; Alves, É.A.R.; Calzavara-Silva, C.E. Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue. Viruses 2018, 10, 104.

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