Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton
1
Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead NSW 2145, Australia
2
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney NSW 2109, Australia
*
Authors to whom correspondence should be addressed.
Viruses 2018, 10(2), 92; https://doi.org/10.3390/v10020092
Received: 24 January 2018
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Revised: 16 February 2018
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Accepted: 20 February 2018
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Published: 23 February 2018
(This article belongs to the Special Issue Cytoskeleton in Virus Infections)
Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV-1 to harness the neuronal cytoskeleton, molecular motors, and the secretory and exocytic pathways for efficient virus entry, axonal transport, replication, assembly, and exit from the distinct functional compartments (cell body and axon) of the highly polarized sensory neurons.
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Keywords:
herpes simplex virus; neurons; axonal transport; cytoskeleton; microtubules; actin
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MDPI and ACS Style
Miranda-Saksena, M.; Denes, C.E.; Diefenbach, R.J.; Cunningham, A.L. Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton. Viruses 2018, 10, 92. https://doi.org/10.3390/v10020092
AMA Style
Miranda-Saksena M, Denes CE, Diefenbach RJ, Cunningham AL. Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton. Viruses. 2018; 10(2):92. https://doi.org/10.3390/v10020092
Chicago/Turabian StyleMiranda-Saksena, Monica, Christopher E. Denes, Russell J. Diefenbach, and Anthony L. Cunningham. 2018. "Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton" Viruses 10, no. 2: 92. https://doi.org/10.3390/v10020092
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