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Viruses 2018, 10(2), 92;

Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton

Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead NSW 2145, Australia
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney NSW 2109, Australia
Authors to whom correspondence should be addressed.
Received: 24 January 2018 / Revised: 16 February 2018 / Accepted: 20 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Cytoskeleton in Virus Infections)
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Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV-1 to harness the neuronal cytoskeleton, molecular motors, and the secretory and exocytic pathways for efficient virus entry, axonal transport, replication, assembly, and exit from the distinct functional compartments (cell body and axon) of the highly polarized sensory neurons. View Full-Text
Keywords: herpes simplex virus; neurons; axonal transport; cytoskeleton; microtubules; actin herpes simplex virus; neurons; axonal transport; cytoskeleton; microtubules; actin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Miranda-Saksena, M.; Denes, C.E.; Diefenbach, R.J.; Cunningham, A.L. Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton. Viruses 2018, 10, 92.

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