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The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis

Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA
Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA
Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA
NCI HPV Workshop, DCEG, Rockville, MD 20850, USA
Departments of Pediatrics, Microbiology and Immunology, Epidemiology and Population Health, and Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Authors to whom correspondence should be addressed.
Attendees (not already listed as co-authors, alphabetical order): Laia Alemany, Lawrence Banks, Sara Bass, Chris Buck, Laurie Burdett, Anil Chaturvedi, Gary Clifford, Daniel DiMaio, John Doorbar, Allan Hildesheim, Lou Laimins, Paul Lambert, Hong Lou, Alison McBride, Karl Munger, Miguel Angel Pavón Ribas, Ligia Pinto, John Schiller, Richard Schlegel, Stefan Schwartz, Mia Steinberg, Sarah Wagner, Yanzi Xiao, Qi Yang, Kai Yu, Bin Zhu (Supplementary Materials Table S1 lists attendee affiliations).
Viruses 2018, 10(2), 80;
Received: 9 December 2017 / Revised: 24 January 2018 / Accepted: 12 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Expert Views on HPV Infection)
Of the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms. Understanding the mechanisms of HPV genomic findings is complicated by the linkage of HPV genome variants. A panel of experts in various disciplines gathered on 21 November 2016 to discuss the interdisciplinary science of HPV oncogenesis. Here, we summarize the discussion of the complexity of the viral–host interaction and highlight important next steps for selected applied basic laboratory studies guided by epidemiological genomic findings. View Full-Text
Keywords: HPV carcinogenesis; HPV epidemiology; HPV genomics; viral–host interactions; HPV16 HPV carcinogenesis; HPV epidemiology; HPV genomics; viral–host interactions; HPV16
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Mirabello, L.; Clarke, M.A.; Nelson, C.W.; Dean, M.; Wentzensen, N.; Yeager, M.; Cullen, M.; Boland, J.F.; NCI HPV Workshop; Schiffman, M.; Burk, R.D. The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis. Viruses 2018, 10, 80.

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