Next Article in Journal
The Application of NHEJ-CRISPR/Cas9 and Cre-Lox System in the Generation of Bivalent Duck Enteritis Virus Vaccine against Avian Influenza Virus
Next Article in Special Issue
Expert Views on HPV Infection
Previous Article in Journal
Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
Previous Article in Special Issue
Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessMeeting Report
Viruses 2018, 10(2), 80; https://doi.org/10.3390/v10020080

The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis

1
Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA
2
Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA
3
Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA
4
NCI HPV Workshop, DCEG, Rockville, MD 20850, USA
5
Departments of Pediatrics, Microbiology and Immunology, Epidemiology and Population Health, and Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Attendees (not already listed as co-authors, alphabetical order): Laia Alemany, Lawrence Banks, Sara Bass, Chris Buck, Laurie Burdett, Anil Chaturvedi, Gary Clifford, Daniel DiMaio, John Doorbar, Allan Hildesheim, Lou Laimins, Paul Lambert, Hong Lou, Alison McBride, Karl Munger, Miguel Angel Pavón Ribas, Ligia Pinto, John Schiller, Richard Schlegel, Stefan Schwartz, Mia Steinberg, Sarah Wagner, Yanzi Xiao, Qi Yang, Kai Yu, Bin Zhu (Supplementary Materials Table S1 lists attendee affiliations).
*
Authors to whom correspondence should be addressed.
Received: 9 December 2017 / Revised: 24 January 2018 / Accepted: 12 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Expert Views on HPV Infection)
Full-Text   |   PDF [685 KB, uploaded 13 February 2018]   |  

Abstract

Of the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms. Understanding the mechanisms of HPV genomic findings is complicated by the linkage of HPV genome variants. A panel of experts in various disciplines gathered on 21 November 2016 to discuss the interdisciplinary science of HPV oncogenesis. Here, we summarize the discussion of the complexity of the viral–host interaction and highlight important next steps for selected applied basic laboratory studies guided by epidemiological genomic findings. View Full-Text
Keywords: HPV carcinogenesis; HPV epidemiology; HPV genomics; viral–host interactions; HPV16 HPV carcinogenesis; HPV epidemiology; HPV genomics; viral–host interactions; HPV16
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Mirabello, L.; Clarke, M.A.; Nelson, C.W.; Dean, M.; Wentzensen, N.; Yeager, M.; Cullen, M.; Boland, J.F.; NCI HPV Workshop; Schiffman, M.; Burk, R.D. The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis. Viruses 2018, 10, 80.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top