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Open AccessCase Report
Viruses 2018, 10(1), 44;

Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore

Environmental Health Institute, Singapore 138667, Singapore
Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
CMC Wong Binjai Clinic, 15 Binjai Park, Singapore 589824, Singapore
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 11 January 2018 / Accepted: 12 January 2018 / Published: 18 January 2018
PDF [3606 KB, uploaded 18 January 2018]


We report a case of a Singaporean who acquired Zika virus (ZIKV) during a visit to Cuba. The infection was confirmed using molecular and serological methods. This report highlights potential drawbacks of using IgG serology for diagnosis of flavivirus infections in endemic regions. The low viremia detected during the early phase of this case resulted in low mosquito infectivity rates, suggesting the possibility of ZIKV transmission prior to clinical onset. The report also emphasizes the challenges of public health interventions for Zika fever and the importance of sustaining a low vector population to reduce the risk of arbovirus transmission in vulnerable regions. View Full-Text
Keywords: Zika virus; antibody; mosquito Zika virus; antibody; mosquito

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Tan, C.H.; Tan, L.K.; Hapuarachchi, H.C.; Lai, Y.L.; Wong, P.S.J.; Yap, G.; Mak, K.W.; Wong, W.Y.; Leo, Y.S.; Wong, M.C.; Ng, L.C. Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore. Viruses 2018, 10, 44.

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