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Viruses 2018, 10(1), 29; https://doi.org/10.3390/v10010029

A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80524, USA
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Received: 1 December 2017 / Revised: 3 January 2018 / Accepted: 8 January 2018 / Published: 10 January 2018
(This article belongs to the Section Animal Viruses)
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Abstract

Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma. The original research conducted on FeLV employed classical virological techniques. As methods have evolved to allow FeLV genetic characterization, investigators have continued to unravel the molecular pathology associated with this fascinating agent. In this review, we discuss how FeLV classification, transmission, and disease-inducing potential have been defined sequentially by viral interference assays, Sanger sequencing, PCR, and next-generation sequencing. In particular, we highlight the influences of endogenous FeLV and host genetics that represent FeLV research opportunities on the near horizon. View Full-Text
Keywords: feline leukemia virus; endogenous retroviruses; retroviruses; phylogenetic analysis; subgroup classification; viral interference assays; Sanger sequencing; PCR; next-generation sequencing feline leukemia virus; endogenous retroviruses; retroviruses; phylogenetic analysis; subgroup classification; viral interference assays; Sanger sequencing; PCR; next-generation sequencing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chiu, E.S.; Hoover, E.A.; VandeWoude, S. A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing. Viruses 2018, 10, 29.

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